Vulvar pruritus is a common and distressing condition that affects nearly all women at some point in their lives. Vulvar pruritus describes an itch that feels good when scratched versus an itch that may be desc
We used least square means to account for missing data or unbalanced design and incorporated 95% CIs. Post hoc analysis using the Wilcoxon signed-rank test was performed to evaluate weekly PP-NRS at week 2 compared with baseline. For the secondary end points, we evaluated improvements from ...
is a prevalent and bothersome symptom associated with cutaneous conditions (such as psoriasis, atopic dermatitis [AD], lichen planus [LP], etc.); however, primarily extracutaneous ailments may also play a role in the occurrence of CP [1,2]. Prominent examples...
As used in the context of the present disclosure, the expression “activating PAR-2 protease cleavage site” means the junction of residues Arg-36 and Ser-37 of human PAR-2 (SEQ ID NO:851). The activating PAR-2 protease cleavage site is the site which, when cleaved, results in the for...
Predictors of oEEG utilization in standard clinical settings were established by means of both univariate and multivariate analyses.Of the 507 patients studied, 83 (which accounts for 164% of the sample) underwent oEEG. The factors contributing to the use of oEEG were found to be age (OR =...
HPLC means high performance liquid chromatography. Room temperature means 20 to 25° C. EXAMPLES Example 1 1-Benzyl-3,4-dimethyl-4-(3-(5-(trimethylsilyl)-1H-1,2,3-triazol-4-yl)phenyl)piperidine To a solution of (trimethylsilyl)diazomethane (2.0 M in hexane, 9.86 mL, 19.7 mmol) in ...
• Menopause – Reaching this time of life has the same effect as breastfeeding -- low estrogen levels. Advancing age also means that your skin is thinner than it used to be and this can make you more prone to itching and infections. • Medication side-effects – Certain medicines can...