Introduction Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules distributed on the trunk and extensor surfaces of the extremities. PN has a profoundly negative impact on sleep and quality of life in patients with PN. There are ...
Prurigo nodularis in HIV infection is uncommon and, in this patientpopulation, is refractory to all other treatments, making it difficult to enroll patients to receive placebo. While we were able to randomize for doseof thalidomide, blinding for placebo is difficult because of the sedating effect...
The aim of this study was to describe the use of thalidomide in the treatment of prurigo nodularis Hyde (PNH) refractory to other treatments or in cases where other treatments cannot be used due to side effects. 77 medical records were retrospectively reviewed for the following data: sex, age...
Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab. J Allergy Clin Immunol. 2022;149(4):1329-1339. doi:10.1016/j.jaci.2021.10.004Google ScholarCrossref 19. Williams KA, Roh YS, Brown I, et al. Pathophysiology, diagnosis, and ...
As diagnosis rates improve, the demand for effective therapeutic options rises, encouraging pharmaceutical companies to develop and market new treatments. This growing recognition and understanding of prurigo nodularis are essential drivers in expanding the treatment market. Opportunities Development of New ...
Prurigo nodularis (PN) is a barely-known disease that causes considerable impairment of quality of life for which very scarce treatment alternatives are available.1 Recently, biological drugs and small molecules have been used as off-label treatments. In this article, we report the case of PN tr...
“The present analysis provides evidence that the SD NRS is a reliable and valid PRO measure that can be used for capturing changes in loss of sleep in prurigo nodularis in daily practice and clinical trials,” they concluded. Ongoing research is recommended, however, to confirm their findings,...
The term “prurigo nodularis” (or “PN”) is used herein as it is in the art and means a skin disease that causes hard, itchy lumps (nodules) to form on the skin. The itching (pruritus) can be intense, causing people to scratch themselves to the point of bleeding or pain. Scratchin...
Disclosure Tianhao Li and Pingsheng Hao are co-correspondence authors for this study. The authors have no conflicts of interest to declare in this work. References 1. Williams KA, Roh YS, Brown I, et al. Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis. Expert Rev...
Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularisPrurigo nodularisitchpruritusepidemiologyclinical featuresphysical examsymptomscomorbiditiesIntroduction: Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules distributed on ...