在人 IPF 组织来源的精准切割肺切片(PCLS)模型中,PRS-220 也能有效抑制纤维化重塑,下调 COL1A1 蛋白表达,展现出良好的抗纤维化活性。 独特的药物特性优势 :PRS-220 是一种 Anticalin 蛋白,具有适宜的大小(约 18 - 20kDa)和紧...
凤凰网港股|Pieris制药公司(PIRS)宣布开发PRS-220,一种针对结缔组织生长因子(CTGF)(CCN2的口服吸入性抗癌蛋白),用于治疗特发性肺纤维化(IPF)。 该公司还宣布它已被选中获得巴伐利亚州经济事务、地区发展和能源部提供的1700万美元的资助,用于研究和开发PRS-220治疗SARS-CoV-2感染的急性后遗症,或PASC,肺纤维化,或...
PRS-220 is an inhalable Anticalin protein targeting CTGF in development as a novel therapy for fibrotic lung disease including IPF.Objective: We investigate the nebulization performance and in vivo lung biodistribution of PRS-220 to characterize its profile for inhaled lung delivery.Methods: The ...
About PRS-220: PRS-220 is an inhaled Anticalin protein targeting CTGF for the treatment of IPF and other fibrotic lung diseases. Previously reported preclinical data for PRS-220 demonstrated superior on-target potency compared to pamrevlumab, an intravenously infused CTGF antagonist in ...
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IPF IN1201K1 ipf electronic gmbh NSYCEJD30Guarn.?30-31perppcperconnettori LKD9A电缆36600201302563LEONIKerpenGmbHLEONI 16953滚轮173.12905201302032SMW-AUTOBLOKSpannsystemeGmbHSMW 9346361970955 283 201/10 M 160016.1GSMB1ATH250V4,5x16mm 6052156Vibrationsgrenzschalter für Flüssigkeiten LFV330 PV3112 Kraus &...
The preclinical and developability data support further development of PRS-220 as a potential best-in-class inhaled IPF therapy.Vanessa WelkMarina PavlidouClaudia WurzenbergerEva-Maria HansbauerCornelia WurzenbergerStefan GrünerJanet Peper-Gabriel