它通过模式识别受体(pattern recognition receptor, PRR)识别具有病原体相关分子模式(pathogen associated molecular pattern, PAMP)或损伤相关分子模式(damage associated molecular pattern, DAMP)的生物大分子。PAMP包括病原体入侵所带来的一系列生物大分子,如细菌表面的脂多糖(lipopolysaccharide, LPS)、鞭毛、病毒入侵带来...
Callol A,Roher N,Amaro C,et al.Characterization of PAMP/PRR interactions in European eel (Anguilla anguilla)macrophage-like primary cell cultures.Fish and Shellfish Immunology. 2013Callol, A.,Roher, N.,Amaro, C.,MacKenzie, S.. Characterization of PAMP/PRR interactions in European eel (...
Upon PAMP engagement, PRRs trigger complex signal cascades that lead to the production of an appropriate set of cytokines and chemokines, including interferons (IFNs), the enhancement of antigen presentation capacity and the migration of DCs to lymphoid tissues, where the DCs interact with T cells...