Neural crest cells are multipotent progenitors that produce defining features of vertebrates such as the 'new head'. Here we use the tunicate,, to explore the evolutionary origins of neural crest since this invertebrate chordate is among the closest living relatives of vertebrates. Previous studies ...
Ascidian embryos highlight the importance of cell lineages in animal development. As simple proto-vertebrates, they also provide insights into the evolutionary origins of cell types such as cranial placodes and neural crest cells. Here we have determined
The notochord and dorsal ectoderm induce dorsoventral compartmentalization of the vertebrate neural tube through the differential regulation of genes such as HNF-3beta, Pax3, Pax6 and snail. Here we analyze the expression of HNF-3beta and snail homologues in the ascidian, Ciona intestinalis, a memb...
Calcitonin in a protochordate, Ciona intestinalis - The prototype of the vertebrate calcitonin/calcitonin gene-related peptide superfamily The calcitonin (CT)/CT gene-related peptides (CGRPs) constitute a large peptide family in vertebrates. However, no CT/CGRP superfamily members have so far ......
Using these and other representative genomes and developing algorithms for the probabilistic macrosynteny model, we reconstruct high-resolution proto-vertebrate, proto-cyclostome and proto-gnathostome genomes. Our reconstructions resolve key questions regarding the early evolutionary history of vertebrates. ...
is a freshwater puffer fish with the smallest known vertebrate genome. Here, we report a draft genome sequence with long-range linkage and substantial anchoring to the 21chromosomes. Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to ...
The CNS of the protovertebrate Ciona intestinalis contains a single cluster of dopaminergic (DA) neurons, the coronet cells, which have been likened to the hypothalamus of vertebrates. Whole-embryo single-cell RNA sequencing (RNA-seq) assays identified Ptf1a as the most strongly expressed cell-...
Comprehensive single-cell transcriptome lineages of a proto-vertebratedoi:10.1038/s41586-019-1385-yChen CaoLaurence A. LemaireWei WangPeter H. YoonYoolim A. ChoiLance R. ParsonsJohn C. MateseMichael LevineKai ChenNature Publishing Group
Naruse K, Tanaka M, Mita K, Shima A, Postlethwait J, Mitani H: A medaka gene map: the trace of ancestral vertebrate proto- chromosomes revealed by comparative gene mapping. Genome Res 2004, 14:820-8.Naruse K,Tanaka M,Mita K,Shima A,Postlethwait J,Mitani H.A m...
1974, Protochordate immunity: primary immune response of the tunicate Ciona intestinalis to vertebrate erthrocytes, J. Inverteb. Pathol., 24, 29-36.Wright, R. K., 1974, Protochordate immunity, I. Primary immune response of the tunicate dona intestinalis to vertebrate erythrocytes, J. ...