There are two folate-specific members of the superfamily of solute carriers, the reduced folate carrier (RFC-SLC19A1) and the proton-coupled folate transporter (PCFT-SLC46A1). The former was cloned in 1994 [1]; the latter was identified in 2006 [2••]. PCFT, like other proton-couple...
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The proton-coupled folate transporter (PCFT/SLC46A1) displays optimal and prominent folate and antifolate transport activity at acidic pH in human carcinom... N Gonen,EE Bram,YG Assaraf - 《Biochem Biophys Res Commun》 被引量: 109发表: 2008年 Abstract 2528: Therapeutic targeting of a novel 6...
Thymidylate synthase (TS) has a predictive role in pemetrexed treatment of mesothelioma; however, additional chemoresistance mechanisms are poorly understood. Here, we explored the role of the reduced-folate carrier (RFC/SLC19A1) and proton-coupled folate transporter (PCFT/SLC46A1) in antifolate ...
Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. Folate deficiency has been associated with many adverse clinical manifestations. The blood-brain barrier (BBB), formed by brain capillary endothelial cells... X Wang,RM Cabrera...
The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus. Recent work has identified a F392V mutation causing hereditary folate malabsorption. However, the residue properties responsible for this loss of function remains ...
Further embodiments of this invention provide methods for treating cancer, targeting cancerous cells via the proton coupled folate transporter pathway, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthr...
The proton-coupled folate transporter (PCFT) is a proton-folate symporter with an acidic pH optimum, such that PCFT may provide a mechanism for targeting cytotoxic antifolates to tumors, based on their acidic microenvironments (pH 6.2-6... SK Desmoulin,W Lei,L Tait,... - 《Cancer Research...
Expression of proton-coupled folate transporter (PCFT) is associated with survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia, prompting studies to elucidate their correlation.Modulation of glycolytic gene expression was evaluated by PCR arrays in tumour cells and primary...
Hereditary folate malabsorption is a rare inborn error of metabolism due to mutations in the proton-coupled folate transporter ( PCFT). Clinical presentation of PCFT deficiency may mimic severe combined immune deficiency (SCID). We report a 4-month-old female who presented with failure to thrive,...