Matured DCs migrate to the dermis and to the lymph node under the influence of cytokines and chemokines that are secreted by keratinocytes and fibroblast in the dermis (OECD, 2014; Sumpter et al., 2019). During maturation, cell surface markers, adhesion molecules, cytokines, and chemokines are...
Briefly, 10 × 106 viable cells were suspended in 0.1 ml PBS and injected intramuscularly into 10 athymic mice (4–7 weeks old). Considering the princi- ple of "reduction" in animal experiments, we decided to CD marker expression and differentiation capacity in different sera ...
fibroblast activity in vitro and alters the phenotype of mesangial cells to a more fibroblast-like phenotype [22,23]. Transgenetic mice overesxpressing TGF-β1 show increased renal fibrosis [24,25]. Thus, TGF-β1 appears to play a central role in the development of renal fibrosis [26]. Bo...
and several hepatokines have been associated with metabolic dysfunctions [25,26]. Hepatokines are suggested to change during HBV infection. Increased plasma levels of the hepatokine Fibroblast Growth Factor 21 (FGF-21) are associated with hepatic steatosis [27], but ...
A faster telogen-to-anagen transition was also seen compared with control mice (Li et al., 2012b). Angiogenesis and increased vascularization of the follicle are thought to be critical for the initiation of the anagen phase (Mecklenburg et al., 2000). Conversely, reduced blood flow and ...
fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and ...