Protocellminimal cellorigin of lifeRNA worldvesiclesprebiotic chemistrypeptidesprotometabolismThe traditional route to investigating biology by perturbing living systems or by individually purifying and characterizing component parts is giving way to more complex endeavors where chemists and physicists attempt ...
The RNA world hypothesis assumes thatlifeoriginates from self-replicating RNA, a biomolecule which was present before the evolution of DNA and proteins. However, researchers assume that on an early planet Earth concentrations of RNA and their building blocks may have been too dilute for a reaction...
CHEMICAL ORIGIN OF LIFE Pulling apart protocellsHadi M. Fares Nature Chemistry volume 14, pages 5–6 (2022)Cite this article 1620 Accesses 3 Altmetric Metrics details Membraneless coacervate droplets have been widely investigated as potential candidates for early cells or protocells. Now, they are ...
A biochemist, he was responsible for a series of discoveries about the origin of life. Fox believed in the process of abiogenesis, by which life spontaneously organized itself from the colloquially known “primordial soup,” poolings of various simple organic molecules that existed during the time...
Revealing the origin of life and unambiguously detecting fossil remains of the earliest organisms are closely related aspects of the same scientific research. The synthesis of prebiotic molecular building blocks of life and the first compartmentalization into protocells have been considered two events ...
It has been proposed that during the early steps in the origin of life, small droplets could have formed via the segregation of molecules from complex mixtures by phase separation. These droplets could have provided chemical reaction centres. However, wh
"This should bring molecular controlcircuitscloser to practical applications and provide new insights into how protocells capable of information processing might have operated at the origin of life."
"This should bring molecular controlcircuitscloser to practical applications and provide new insights into how protocells capable of information processing might have operated at the origin of life."
Coacervate droplets are promising protocell models because they sequester a wide range of guest molecules and may catalyze their conversion. However, it remains unclear how life’s building blocks, including peptides, could be synthesized from primitive
We speculate that our results could provide a feasible pathway to autonomous protocell diversification in origin of life theories and highlight the possible role of solid surfaces in the development of diversity and rudimentary speciation of natural protocells on the early Earth.ChemSyst...