The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by . Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. 被引量: ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook (redirected fromProtooncogene) Dictionary Medical Encyclopedia </>embed</> factor gene cistron transforming... oncogene noun Synonyms for oncogene nouna gene that disposes normal cells to change into cancerous tumor ...
2、生长因子受体(质膜):具酪氨酸蛋白激酶活性,如neu,ht,met,erbB,trk,fms,ros-1等。 3、非受体酪氨酸蛋白激酶(质膜/胞质),如src家族:src,syn,fyn,abl,lck,ros,yes,fes,ret等。 4、丝氨酸/苏氨酸蛋白激酶(胞质):如raf,raf-1,mos,pim-1。 5、G蛋白(质膜内侧),具GTP结合作用和GTP酶活性,如ras家族中...
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. A new human gene encoding a receptor-type tyrosine kinase was isolated by a weak cross-hybridization with v-ros oncogene. A cDNA of about 7.7 kb carried a ... M...
MET, mesenchymal-epithelial transition; ROS1, receptor tyrosine kinase encoded by theROS1gene; IGF-1, insulin-like growth factor 1; IGF1R, IGF-1 receptor. 5.3.5Trk inhibitors Entrectinibis a selective inhibitor of Trk, ALK, and ROS1. Iyer et al. examined the potential efficacy of entre...
In vitro studies have indicated that reactive oxygen species (ROS) and the oxidation of signaling molecules are important mediators of signal transduction... Y Shibata,R Branicky,IO Landaverde,... - 《Science》 被引量: 1053发表: 2003年 Protein Interaction Mapping in C. elegans Using Proteins...
Comparative role of phosphotyrosine kinase domains of c-ros and c-ret protooncogenes in metanephric development with respect to growth factors and matrix morphogens. Dev. Biol 1996;178:133-148. [PubMed: 8812115]Z. Z. Liu, J. Wada, A. Kumar, F. A. Carone, M. Takahashi, and Y. S....
HER2 is an oncogene that is located on chromosome 17q and encodes the 185 kDa tyrosine kinase receptor protein [23,25]. HER2 is a protein that is a member of the epidermal growth factor receptor (EGFR) family [26,27]. The overexpression of HER2 is found in breast, ovarian, lung, and...