The Proteomics Drug Atlas 2023 was used to predict candidate hub protein drugs. To confirm the expression of the candidate factor, protein tyrosine phosphatase receptor S (PTPRS), in psoriatic lesions and the psoriatic keratinocyte model, immunohistochemical staining, quantitative real-time polymerase ...
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et al. Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities. Oncogene 42, 1661–1671 (2023). Article CAS PubMed PubMed Central Google Scholar Kanwal, M., Smahel, M., Olsen, M., Smahelova, J. & Tachezy, R. Aspartate ß-hydroxylase as a target for cancer...
Thus, except for MEKi, no new targeted drug has achieved improvements in PFS or OS when compared with treatments approved by FDA. Notably, we found that although these clinical trials for targeted therapies have tried to select patients for the various arms of the study based on the presence ...
(Fig. 5). In the examination of the immunohistochemical staining of in normal and cervical cancer tissues in The Human Protein Atlas database, the cancer tissues displayed enhanced staining strength and intensity of PRDX2 protein, chiefly expressed in the cytoplasm and cell membrane. (Fig. 5b)...
Interdisciplinary research team developing novel drug detection technology New system uses software that acts like a robotic scientist analytica-world.com Microbe of the Year 2023: Bacillus subtilis – for health and technology Already, Bacillus subtilis is indispensable in many industries, and many ...
Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B (2007) Functional atlas of the integrin adhesome. Nat Cell Biol 9:858–867 Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DHJ, Askari JA, Humphries MJ (2015) Isolation of integrin-based...
Proteomics, as a platform technology of cellular protein expression, modification, and interaction, has provided innovative perspectives on early diagnosis, treatment, and targeted drug development for HCC. This review summarizes recent progress in proteomics for advancing HCC biomarker discovery, drug ...
To map biomarker proteins to gene expression data, we investigated the expression of ATI biomarker-corresponding genes using regional transcriptomics and scRNA-seq data from KPMP (https://atlas.kpmp.org/explorer; access date: August 1, 2023). Tissue samples used for regional transcriptomics were ...
Atlas website85. We used 2587 proteins classified as brain-elevated from the Human Protein Atlas dataset to compare our EV protein and phosphoprotein data. We found that 8.9% of our EV proteins were denoted as brain-elevated (Supplementary Fig.3). While the brain is likely a minimal source ...