Biallelic mutations affecting either of the two proteins result in IGS in men and dogs [19]. Recent studies aimed at identifying the causative genes and molecules in suspected cases of IGS, revealed defects in the gastric intrinsic factor gene (GIF). Thus, these cases cannot be classified as ...
IGS has been found in dogs, first in Giant Schnautzers [22]. Heet al.[23] demonstrated a linkage of canine IGS to chromosome 8 in a region orthologous to human chromosome 14q32.2-ter, in an interval that contains theAMNgene. Further studies showed that effective cubam expression does no...