L. (2002). Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity. Gene Ther. 9: 1422 - 1428.Leifert JA,Harkins S,Whitton JL.Full-length proteins attached to the HIV tat protein transduction domain are ...
Selected expression profiling of full-length proteins and their variants in human plasma. Clin. Proteomics - Kiernan, Nedelkov, et al. - 2004 () Citation Context ...a small scale [21–31]. More important, however, was the fact that new PTMs were discovered for several plasma proteins, ...
Full size image Generally, TRIM proteins are E3 ubiquitin ligases based on their RING domain [7]. B-box domains contain one or two different zinc-binding motifs and are divided into 2 types. They promote the catalytic effect of RING or mediate ubiquitination of substrates independently [8, 9...
The present invention relates to novel methods for making fusion proteins comprising a cytokine or growth factor fused to an immunoglobulin domain. The growth factor/cytokine can be fused directly to an immunoglobulin domain or through a peptide linker. The purified growth factor/cytokine-IgG fusion ...
Full size table It can be seen that proteins containing disordered regions of length ≥ 41 AA are (on average) significantly longer than an average protein in the whole dataset (33-34%, p-value < 0.001 for random samples of 5% of protein sets, using the independent-samples t test for me...
A large collection of 17,855 interacting pairs from 6,429 proteins are adopted to generate different unbalanced datasets with 1:1~1:15 positive-to-negative ratios. As illustrated by the experimental results, the proposed feature set achieves the best prediction performance when compared with two ...
In the nucleus, some RNA-binding proteins (RBP) often function as AS regulators in a particular way in the disease course [13, 14]. Functional disruptions in RBPs may be a major cause or consequence of a disease [15, 16]. CUGBP Elav-like family (CELF) and muscleblind-like (MBNL) ...
Full size image Although inclusion bodies are mainly found in the cytoplasm, they occur also in the bacterial periplasm if proteins have been engineered to present a leader peptide for secretion [121]. In fact, a control quality system mostly separated from that acting in the cytoplasm assist ...
Full size table To quantify the metastability limits of the proteins in terms of the chemical environment, one can assess the energetics of formation reactions for the proteins. At metastable equilibrium, the predominant protein in a population is the one with the highest chemical activity (in this...
One of the leading current trends in technology is the miniaturization of devices to the microscale and nanoscale. The highly advanced approaches are based on biological systems, subjected to bioengineering using chemical, enzymatic and recombinant metho