Plant-derived extracellular vesicles (EVs) gain more and more attention as promising carriers of exogenous bioactive molecules to the human cells. Derived from various edible sources, these EVs are remarkably biocompatible, biodegradable and highly abund
It is also important to observe that the exclusion of structures containing too many (more than 5%) hetero-atoms ensures that crystal contacts due to the presence of co-crystallized small molecules (the so called packing bridges) are minimized. Analogously, the exclusion of incomplete structures, ...
Antimicrobial peptides play a pivotal role as key effectors of the innate immune system in plants and animals and act as endogenous antibiotics. The molecules exhibit an antimicrobial activity against bacteria, viruses, and eukaryotic pathogens with different specificities and potencies depending on the ...
AS is a principal mode of genetic regulation and possibly one of the most widely used mechanisms; it accounts for the complexity of large molecules and cells in higher eukaryotes [6, 7]. AS produces various transcripts from approximately 95% of multiexon human genes, varying the transmission ...
Many characterised proteins contain metal ions, small organic molecules or modified residues. In contrast, the huge amount of data generated by genome projects consists exclusively of sequences with almost no annotation. One of the goals of the structura
Because these Bak molecules would have “used up” their BH3 regions/binding pockets to form the dimer, they must use another binding surface to join with other dimers in forming oligomers. Through mutagenesis, these investigators identified a site on the α6 helix of Bak that would allow pre...
Gold can be directly conjugated using thiolated (-SH) molecules to form stable monolayer-protected particles (Fig. 2) in an interaction that is partially covalent (~35%) and mostly electrostatic (~65%) [48,49]. The monolayer stabilizes the core and can be tailored with a range of function...
but unless they have a very high sequence homology, no conclusion can be drawn from a structural comparison of individual TM helices. More complex supersecondary constructs (made up of 2 or more TM helices) can, however, show structural similarities that may point to an evolutionary duplication....
7F), suggesting the potential binding ability of hydrophobic molecules. Although functional annotation via GO terms was lacking for this subgroup of PR-10 proteins, we recently noticed the sharp upregulation of a novel uncharacterized PR-10 protein (LOC110648447; former accessions XP_021658364.1, XP...
Introduction Cilia and flagella, conserved antenna-like structures protruding from cell surfaces, harbor a number of signaling-associated molecules that maintain cellular homeostasis and regulate tissue development1,2,3. To control the specific ciliary composition, a specialized zone at the base of cilia...