resulting in the disease named COVID-19.1Coronavirus possesses the largest RNA genome among all the RNA viruses. Its genome encodes about 29 proteins (Supplementary Fig. S1). The subcellular distributions of the viral proteins have yet been reported for SARS-CoV-2. It ...
Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19, 1720–1730 (1999). One of the original studies attempting to correlate proteins with mRNA abundance. Gygi and colleagues note that coverage bias may greatly affect across-gene correlations. CAS PubMed PubMed Central ...
Cell signaling requires transient yet highly specific protein interactions, signal sensitivity, signal integration and amplification, and mechanisms to activate/inactivate the entire process in response to changes in the chemical or physical environment. Intrinsic disorder provides the functional diversity, int...
Therefore, the intuitive expectation is that such a procedure will also work for SCL—in other words, that a protein tends to stay in the same compartment in the course of evolution. Indeed, a significant part of the “subcellular location” annotations of Swiss-Prot (the manually annotated ...
Photoaffinity labelling with [α- 32P]GTP allowed to detect a 54 kDa GTP-binding protein in rat pancreatic plasma membranes and in pancreatic AR 4-2J cell membranes. Like the 42 and 48 kDa G sα subunits and the 41 kDa G iα subunit, this protein was absent from zymogen granule membran...
The relative metastabilities of the reference model proteins are compared with some observations from the literature about reaction progress during the cell cycle. Specific known interactions between compartments are considered in order to derive values of the oxygen fugacity within compartments that best ...
The factors that underlie the expansion of this gene family in plants are not as yet understood. Results We show that the location of PPR genes is highly variable in comparisons between orthologous, closely related, and otherwise co-linear chromosomal regions of the Brassica rapa or radish and ...
armigeraepidermis cell line cells also repressed 20E-induced autophagosome formation and caspase-3 activation. The results suggested that 20E plays key role in the regulation of ATG12–ATG5 conjugation in a concentration and time-dependent manner for autophagy or apoptosis, and that ATG12 is ...
Most biological membranes have asymmetry in lipid composition between the leaflets of their bilayer6,7. This asymmetry is dependent on membrane type and cell status8, and the plethora of enzymes dedicated to creating and maintaining bilayer asymmetry9,10, as well as disease states featuring mis-...
Fluorescent proteins (FPs) have been used for nearly three decades to probe cell biology1, but the technology is still catching up with striking advances in microscopy methods such as super-resolution imaging2, expansion microscopy (ExM)3 and correlative light and electron microscopy (CLEM)4. FPs...