HSPs help to maintain homeostasis and stability of cellular proteins in many ways, they often work together to perform a combination of events.With some functions not yet understood, it is known that many HSPs have multiple roles. 热休克蛋白有助于以多种方式维持细胞蛋白的稳态和稳定性,它们通常与...
Some G-protein-coupled receptors have been reported to require accessory proteins with specificity for proper functional expression. In this study, we found that CXCR1 interacted with REEP5 and REEP6, but CXCR2 did not. Overexpression of REEP5 and REEP6 enhanced IL-8-stimulated cellular responses...
Pathogenesis-related 10 (PR-10) is a group of small intracellular proteins that is one of 17 subclasses of pathogenesis-related proteins in plants. The PR-10 proteins have been studied extensively and are well-recognized for their contribution to host de
ProtCAD ProtCAD is a suite of tools for the design and engineering of novel protein structures, sequences, and functions. It allows users to build and manipulate complex protein structures, generate and evaluate sequence libraries, and simulate mutational effects. ProtCAD is a suite of tools for...
to N-glycosylation ofCampylobacter jejuni, opening the curtain on the glycoprotein synthesis inE. coli[105] (Fig.3C). Over the last two decades, many efforts have conferred the potential to produce a wide range of N/O-glycoproteins fromE. colior cell-free extracts, including optimization of ...
Lamins are not restricted to the nuclear lamina but associated to the nuclear matrix; therefore lamins are involved not only in maintaining the nuclear architecture but in modulating nuclear functions including DNA replication and transcription (Moir and Spann, 2001). Nuclear lamins are type V ...
There are many aspects of HSP biology that remain puzzling, ranging from their roles under normal conditions to their functions in most various disease states. HSPs have been established to comprise a diverse group of essentially intracellular proteins that share the property of assisting the non-cov...
Many of the mammalian EV marker proteins either have no homologs in fungi, or the homologs are not found in fungal EVs [26]. This has led to the need for de novo identification of fungal EV protein markers based on the recommenda- tions outlined in MISEV2018 [15]. These markers will ...
33. Since most DARPins including those described above have naturally high soluble expression yields in theE. colicytoplasm37, we hypothesized that pE59 variants with enhanced affinity for cognate pERK2 antigen could be readily isolated by simply demanding cell growth on Carb concentrations that would...
It has also become apparent that this common mechanistic principle is structurally adjusted to carry out a diverse array of biological functions. Here, we review how substrate-bound structures of AAA+ proteins have expanded our understanding of ATP-driven protein remodelling. This is a preview of ...