HSPs help to maintain homeostasis and stability of cellular proteins in many ways, they often work together to perform a combination of events.With some functions not yet understood, it is known that many HSPs have multiple roles. 热休克蛋白有助于以多种方式维持细胞蛋白的稳态和稳定性,它们通常与...
including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic compartments. In humans, approximately 60 proteins are involved in nuclear transport, including nucleoporins that form membrane-embedded nu...
Membrane proteins carry out many essential functions in biology and are therefore major drug targets1,2. Recent progress has been made in understanding how membrane proteins fold3, but while lipid–protein interactions are known to be important, their precise roles remain unclear, with most informati...
This kind of protein has one or more repetitive domains formed by short peptide motifs, which can lead to the specific enrichment of several amino acids including glutamine, glycine, and phenylalanine (Labuschagne, 2018). Prolamins extracted from different cereals usually have other common names, ...
Pathogenic variants in many other genes, including protein components of the sarcomere (e.g.TNNT2, TPM1), Z-disk (e.g.TCAP, MYPN, NEXN), cytoskeleton (e.g.DES, VCL), desmosome (e.g.DSP), and RNA-binding proteins (e.g.RBM20), have been reported in DCM cohorts. Individually, the...
ProtCAD ProtCAD is a suite of tools for the design and engineering of novel protein structures, sequences, and functions. It allows users to build and manipulate complex protein structures, generate and evaluate sequence libraries, and simulate mutational effects. ProtCAD is a suite of tools for...
1 Notable is the Ig superfamily, whose members have a diversity of sequences and functions but a common denominator in the recognition role at the cell surface.2 In recent years a large body of information has emerged regarding the structure and biologic function of various proteins that ...
In most of these proteins, CBS domain coexists with other functional domain(s), which may indicate towards their probable functions. In order to investigate the role(s) of these CDCPs, we have carried out their detailed analysis in whole genomes of itArabidopsis /itand itOryza/it, including...
Some G-protein-coupled receptors have been reported to require accessory proteins with specificity for proper functional expression. In this study, we found that CXCR1 interacted with REEP5 and REEP6, but CXCR2 did not. Overexpression of REEP5 and REEP6 enhanced IL-8-stimulated cellular responses...
Pathogenesis-related 10 (PR-10) is a group of small intracellular proteins that is one of 17 subclasses of pathogenesis-related proteins in plants. The PR-10 proteins have been studied extensively and are well-recognized for their contribution to host de