In cardiovascular cells, the proteins have many important physiological functions, including the regulation of platelet activation, endothelial barrier function, cardiomyocyte contraction, conducted vasodilation and smooth muscle relaxation. Since their initial discovery more than three decades ago, much has ...
HSPs help to maintain homeostasis and stability of cellular proteins in many ways, they often work together to perform a combination of events.With some functions not yet understood, it is known that many HSPs have multiple roles. 热休克蛋白有助于以多种方式维持细胞蛋白的稳态和稳定性,它们通常与...
Some G-protein-coupled receptors have been reported to require accessory proteins with specificity for proper functional expression. In this study, we found that CXCR1 interacted with REEP5 and REEP6, but CXCR2 did not. Overexpression of REEP5 and REEP6 enhanced IL-8-stimulated cellular responses...
Pathogenesis-related 10 (PR-10) is a group of small intracellular proteins that is one of 17 subclasses of pathogenesis-related proteins in plants. The PR-10 proteins have been studied extensively and are well-recognized for their contribution to host de
Lamins are not restricted to the nuclear lamina but associated to the nuclear matrix; therefore lamins are involved not only in maintaining the nuclear architecture but in modulating nuclear functions including DNA replication and transcription (Moir and Spann, 2001). Nuclear lamins are type V ...
There are many aspects of HSP biology that remain puzzling, ranging from their roles under normal conditions to their functions in most various disease states. HSPs have been established to comprise a diverse group of essentially intracellular proteins that share the property of assisting the non-cov...
functions between cells, tissues, and organs, and all cells must respond to environmental cues. Many mechanisms have evolved to transmit these signals. Extra-cellular signaling involves releasing or displaying any of a variety of chemicals, which are specifically recognized by a receiving cell that ...
As protein domains, one or more CBMs are generally associated with other protein domains, typically glycosyl hydrolase (GH) modules, and can be localized at either the N or C-termini of proteins, although proteins formed exclusively of single CBMs have been described[3, 4]. Many CBMs have be...
In most of these proteins, CBS domain coexists with other functional domain(s), which may indicate towards their probable functions. In order to investigate the role(s) of these CDCPs, we have carried out their detailed analysis in whole genomes of itArabidopsis /itand itOryza/it, including...
33. Since most DARPins including those described above have naturally high soluble expression yields in theE. colicytoplasm37, we hypothesized that pE59 variants with enhanced affinity for cognate pERK2 antigen could be readily isolated by simply demanding cell growth on Carb concentrations that would...