DNA- and RNA-binding proteins (DRBPs) constitute a significant fraction of cellular proteins and have important roles in cells. Their functions include control of transcription and translation, DNA repair, splicing, apoptosis and mediating stress responses. ...
WFS1 deficiency impairs proinsulin trafficking from the ER to the Golgi in vitro and in vivo During the exploration of the function of WFS1 in pancreatic β-cells, we found an interesting phenomenon in which the distribution of proinsulin was largely different in the scrambled (control) INS1 ce...
Machine learning-aided design and screening of an emergent protein function in synthetic cells Shunshi Kohyama, Béla P. Frohn, Leon Babl & Petra Schwille Nature Communications 15, 2010 (2024) • code Variational auto-encoding of protein sequences Sam Sinai, Eric Kelsic, George M. Church, ...
sheer stress, light). Together, these pathways form an extensive communication network that regulates basic cell activities and coordinates the function of multiple cells or tissues. The process of cell signaling imposes many demands on
Using a genome mining approach to analyse fungal and oomycetal genomes, this study aimed at elucidating the origin and function of CBM1-containing proteins from oomycetes. Accordingly, we revealed a unique combination of domains in these organisms in which CBM1s are linked to PAN/Apple domains....
Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. In the present study we used an adoptive transfer model with athymic nude mice to characterize the T cells involved in initiating and mediating skin allogr... Rosenberg,A. S. -...
Thirdly, interferon is known to affect profoundly a number of in vitro functions of immunocompetent cells.doi:10.1016/0022-1759(80)90331-2J. BeckH. EnglerH. BrunnerH. KirchnerElsevier B.V.Journal of Immunological Methods... J Beck,H Engler,H Brunner,... - 《Journal of Immunological Methods...
Figure 2. Robust editing efficiencies in cancer cells.TrueGuide Synthetic gRNAsfor three genes plus negative control were complexed with TrueCut Cas9 Protein v2; the RNP complexes were delivered into A549, U2OS, or MDA-MB231 cells usingLipofectamine CRISPRMAX Cas9 Transfection Reagent. At 72 hours ...
et al. The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep. 12, 581–586 (2011). Article CAS PubMed PubMed Central Google Scholar Leung, A. K. et al. Genome-wide identification of AGO2 binding sites from mouse embryonic stem cells ...
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