A new challenge for the field is to use these designs directly in cells to intervene in biological processes and augment natural systems. The bottom-up design of self-assembled objects such as microcompartments and membraneless organelles is one such challenge. Here we describe the design of ...
A fundamental problem of cell biology and biochemistry is the elucidation of the mechanisms by which the specific components of subcellular membranes are assembled into mature organelles. The major components of all cell membranes are li... DR Voelker - 《New Comprehensive Biochemistry》 被引量: 39...
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date information on the molecular determinants regulating cell surface expression and trafficking of group I mGluRs and discusses the role of few of these PSD proteins in these processes. As substantial evidences link mGluR dysfunction and maladaptive functioning of many PSD proteins to the pathophysiolo...
Structural DNA nanotechnology enables rapid production of self-assembled nanostructures as demonstrated by DNA tiles (Seeman, 1982) and DNA origami (Rothemund, 2006). Key features of the technology are the addressability of DNA surface with defined location in sequence-driven manner and the versatility...
Distinct RII-binding proteins mediate association of PKAII isoforms with peroxisomes, mitochondria, and other organelles in a variety of cell types (1, 2, 10, 11). These AKAPs have 20-residue RII-binding sites that are homologous with the RII-binding domain in AKAP75 (1, 2,6, 10, 11...
cellular pathways [206,207,208,209,210]. In humans, there are 23 Gα, 6 Gβ, and 12 Gγ subunits that can be assembled into numerous different heterotrimers [211]. Furthermore, cells contain ~ 40 of the regulator of G signaling (RGS) proteins (which are G protein effectors, ...
organelles (e.g. ER-resident chaperones, foldases, components of the translocon). Interestingly, genes encoding proteins involved in protein degradation, vesicular trafficking, lipid biogenesis and vacuolar sorting are also induced by Hac1 [94]. In this context, Higashio and Kohno [95] describe ...
Functional ion channels can be assembled from both homomeric and heteromeric combinations of the seven P2X receptor subunits so far identified (P2X1–7). Due to the lack of specific agonists or antagonists for P2X receptors, it is...
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic proteins that mediate membrane fusion between organelles and with the plasma membrane. SNAREs are directly or indirectly anchored to membranes. Prior to fusion, complementary SNAREs as...