Enzymes that digest proteins into smaller fragments. In shotgun proteomics, proteins are digested into peptides by sequence-specific proteases (such as trypsin, which cleaves proteins at the carboxy-terminal side of lysine and arginine residues). Lipopolysaccharide (LPS). A structural component of the...
2. Recent progress has been made in understanding how membrane proteins fold3, but while lipid–protein interactions are known to be important, their precise roles remain unclear, with most information gleaned empirically on a case-by-case basis4,5. Most biological membranes have ...
On the other hand, immobilization of proteins is necessary in many technical applications in which enzymes are used as catalysts. Also, chromatographic purification of proteins requires a defined interaction of the biomolecules with the column material [5]. In recent years, adsorption of proteins to...
functions carried out by G protein-coupled receptors (GPCRs), which are transmembrane proteins; the nuclear factors of activated T cells (NFATs), which are transcription factors; and the Src family kinases (SFKs), which are signaling enzymes, are all modulated by the collaboration of PTMs and...
Hormone deprivation-induced apo-ptosis in granulosa cells of mouse antral follicles incubated for 24 h was attenuated by two specific peptide inhibitors of caspases, zVAD-FMK and zDEVD-FMK (50-500 microM), confirming that these enzymes are involved in this paradigm of cell death. Proteolysis of...
The emulsification properties of proteins are always related to their structure. One of the crucial properties of the protein for use as an emulsifier is its instantaneous or potential amphiphilicity. The position and composition of the individual amino acids along the polypeptide chain determines the ...
Context-dependent design of induced-fit enzymes using deep learning generates well-expressed, thermally stable and active enzymes Lior Zimmerman, Noga Alon, Itay Levin, and Gideon D. Lapidoth Proceedings of the National Academy of Sciences 121.11(2024) Design of Repeat Alpha-Beta Proteins with Cappi...
Currently, instance has no separate ID, but external Xref(s) should be provided (while Xref is not always available for the parent term). The other attributes of instance are centre (for proteins containing more than one bioinorganic/small molecule centre) and state (e.g. "reduced", "CO-...
232Although these proteins may undergo SUMOylation during nuclear entry, their SUMOylation may also occur inside the nucleus by other SUMO E3 ligases. In fact, most SUMO-modifying enzymes and SUMOylated proteins, including many kinetochore proteins, are found in the nucleus.233,234For example, ...
Pathogenesis-related 10 (PR-10) is a group of small intracellular proteins that is one of 17 subclasses of pathogenesis-related proteins in plants. The PR-10 proteins have been studied extensively and are well-recognized for their contribution to host de