Life on the edge: a link between gene expression levels and aggregation rates of human proteinsTartagliaG. G.PechmannS.DobsonC. M.VendruscoloM.TRENDS IN BIOCHEMICAL SCIENCES -MONTHLY EDITION-Tartaglia GG, Pechmann S, Dobson CM, Vendruscolo M. Life on the edge: a link between gene ...
The method further comprises assessing changes in gene expression levels, levels of nucleic acids, proteins, or protein activity levels and determining whether the compound mimics effects induced by the CR diet program.Stephen SpindlerJoseph Dhabi...
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. Here we review recent mRNA–protein correlation st...
gene expression showed a ~ 23-fold increase. FV protein was present in both healthy and affected CE. Further gene expression analysis of coagulation factors interacting with FV revealed a ~ 34-fold increase of thrombomodulin (THBD). THBD protein was detected only in CE from FECD patie...
(D) Average gene expression levels (RPKM) in each HIR class (Fig. S11). (E) Percentages of the HIRs overlapping with TAD borders or completely localized within TADs. Full size image Next, we classified the HIRs by PCA and hierarchical clustering of enrichment values of 94 of the 177 ...
Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. Peroxisome proliferator-activated receptor (PPAR) gamma is activated by thiazolidinediones (TZDs), widely used as insulin-sensitizing agents for ...
Just as there are many ways the sequence of a gene can influence protein expression and conformation, there are numerous ways in which an alteration in the protein conformation can affect the safety and efficacy of the product. Therefore, the choice of the protein quality attributes measured as ...
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They interact dynamically with RNA to control its biogenesis and turnover by transcription-dependent and transcription-independent mechanisms. In this Review, we discuss the molecular mechanisms by which RBPs allow gene expression changes to occur at different speeds and to varying degrees, and which ...
formation of tDNA foci requires the expression of a functional ComB complex (Tables 1and2and refs11,12) andcomBgenes RNA levels were found to be up-regulated inaddAmutants27, we analysed the relative expression levels of ComB8 and ComB10 proteins in the different DNA repair mutant strains. ...