Two of the proteins named CaBP7 and 8 [15] were also discovered independently and named calneuron 2 and 1 respectively [19, 20]. While these latter two proteins were suggested to be part of the CaBP family [15], others have suggested that the calneurons are a distinct subgroup of the...
Specific classes of antibody aim to neutralize neurotoxic proteins such as amyloid-β fragment 42 (Aβ42) or tau. Entrance to the brain is limited, but these antibodies may also act as a peripheral sink for neurotoxic proteins in the circulation. In the brain, antibodies probably act for the...
irreversible deconjugation18. In addition to its antiviral role, ISG15 can also act as an antibacterial effector against intracellular bacterial pathogens such asListeria monocytogenes6andMycobacterium tuberculosis19and it can restrict the intracellular eukaryotic pathogenToxoplasma gondii20. Despite its broad ...
Ligands of other SPFH proteins have also been identified and shown to act as anesthetics, anti-allodynia, anticancer, and anti-inflammatory agents. These findings indicate that modulators of human or bacterial SPFH proteins can be developed to treat a wide variety of human disorders. Graphical ...
The target specificity, killing efficacy, mode of action, and biochemical properties vary between the peptides. In addition to their antimicrobial activity they can also act as mediators of the adaptive immune system [9] and other cellular processes like wound healing [10]. Most of the peptides...
In addition to different lipids facilitating the targeting of BH3-only proteins to membranes, protein factors that mediate binding of BH3-only proteins to mitochondria or ER are also being identified. Recently the membrane protein MTCH2/MIMP has been discovered as a major facilitator of tBid inse...
(secondary) structure, the energetic barriers between the bound and free states are low, allowing disordered regions to act as reversible, extremely sensitive sensors. In addition to chemical signals, environmental conditions may also instigate signaling pathways that detect mechanical stress, light, pH...
The proteins in exosomes can act as indicators of the health or disease status of cells. They can also control the development of tumors and wider physiological processes that support tumor growth and spread. The authors consider the specific significance of exosome proteins in each of a wide ...
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it also depends upon theirprocessing conditions. The proteins extracted from the cerealgrainsact as an excellent source ofbioactive peptideshaving good health benefits. It improved their nutraceutical/pharmaceutical applications. Higher viscoelastic properties of cereal proteins (especially forglutenproteins) ...