Protein tyrosine kina- se inhibitors: new treatment modalities? Curr Opin Pharmacol. 2002;2:374-81.Fabbro D, Parkinson D, Matter A. Protein tyrosine kinase inhibitors: new treatment modalities? Curr Opin Pharmacol. 2002; 2 :374–381.
TKIs can competitively bind to the kinase structural domains to prevent downstream pathway activation and inhibit tumor growth. Kinase inhibitors, including TKIs, are often classified
Although Tyrosine kinase inhibitors (TKIs) therapy has led to increasing lifespans for many patients with blood and solid cancers, drug resistance and cancer relapse continue to be a major limit. Autophagic pathways with a special focus on the oncogenic pathways, are controlled by receptor tyrosine...
Protein tyrosine kinase inhibitor;Quercetin;Quinone derivative;Resveratrol;Styrene derivative;Terpene derivative;Unclassified drug;Unindexed drug;Antifungal activity;Antimicrobial activity;Antineoplastic activity;Cancer;Cell death;Cell differentiation;Cell function;Cell growth;Clinical trial;Diarrhea;Drug design;Drug ...
Rewcastle et al., " Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2′-dithiobis (1-methyl-N-phenyl-1H-indole-3-carboxamide, " J. Med. Chem. (1994) 37:2033-2042....
Orally active ErbB protein kinase domain inhibitors, Lipinski's rule of five, lipophilic efficiency, and ligand efficiency Pharmacologists and medicinal chemists have searched for drug-like chemical properties that result in compounds with oral therapeutic efficacy in a predictable fashion. Lipinski's “...
Gefitinib_ZD-1839_Iressa_Protein Tyrosine Kinase_EGFR-HER2_CAS号184475-35-2说明书_AbMole中国 分子量446.90 溶解性（25°C）DMSO 89 mg/mL 分子式C H ClFN O Water <1 mg/mL CAS号184475-35-2Ethanol 4 mg/mL 储存条件3年 -20°C 粉末状 生物活性 Gefitinib (ZD1839)是一种EGFR酪氨酸...
研究点推荐 Protein Tyrosine Kinase Inhibitors Protein tyrosine kinases Tyrphostins Therapeutic Agents 引用走势 2003 被引量:14 站内活动 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解...
Identification of potential inhibitors based on compound proposal contest: tyrosine-protein kinase Yesas a target. Sci. Rep. 5, 17209 (2015).Chiba, S. et al. Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target. Sci. Rep. 5, 17209...
5) tyrosine kinase JAK inhibitors 酪氨酸蛋白JAK激酶抑制剂 6) protein-tyrosire-phosphatase/antagonists & inhibitors 蛋白质酪氨酸磷酸酶/拮抗剂和抑制剂 补充资料:酪氨酸蛋白激酶抑制剂 分子式: CAS号: 性质:一类能抑制蛋白质酪氨酸激酶活性的化合物。酪氨酸蛋白激酶能特异性地将磷酸根转移到蛋白质的酪氨酸残基...