The enzymatic methyltransferase function of EZH2 primarily relies on its SET domain, although the N-terminal CXC domain adjacent to the SET domain also plays a crucial contributory role in facilitating this activity135. Mutations in the CXC and SET domains, such as D664A, E549X, C606Y, and ...
Most protein lysine methyltransferases (PKMTs) contain the SET domain, but several non-SET proteins such as DOT1-like histone H3 lysine 79 methyltransferase (DOT1L), methyltransferase-like 10 (METTL10) and METTL21A are also known to have lysineN-methyltransferase activity. Protein lysine demethylase...
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327, 213–216 (2010). CAS PubMed PubMed Central Google Scholar Anderson, E. M. et al. Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, ...
Here we show that mammalian VCP is trimethylated on Lys315 in a variety of cell lines and tissues, and that the previously uncharacterized protein METTL21D (denoted here as VCP lysine methyltransferase, VCP-KMT) is the responsible enzyme. VCP methylation was abolished in three human VCP- KMT ...