1 and 2a). Three types of data are required as input to the generator: the protein’s amino acid sequence, the protein’s structure/auxiliary data and protein-related noise (Fig. 1a). The mutation generator, together with the two discriminators and the binding affinity predictor, are ...
Proton sponge theory refers to the disruption of endosomal compartments due to osmotic swelling via the recruitment of protons that protonate nonexposed amino acid residues in response to the low pH in these organelles58. Membrane disruption, on the other hand, is thought to occur due to the ...
2002. N-terminal N-myristoylation of proteins: Prediction of substrate proteins from amino acid sequence. J Mol Biol 317: 541–557. Article PubMed CAS Google Scholar Maynard TM, Sikich L, Lieberman JA, LaMantia A-S. 2001. Neural development, cell-signaling, and the “two-hit” hypothesis...
glycosylation is a PTM that connects carbohydrates (i.e., sugars) to the amino acid chain of proteins. Depending on where in the protein they are attached, this PTM can be classified into two main groups, namely N-linked glycosylation [connected via an asparagine (N) residue] or O-linked...
the NLs/Nrxs interaction causes an increase in PSD-95 clustering and the recruitment of post-synaptic NMDA (N-methyl-D-aspartate) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors (Nam and Chen,2005; Heine et al.,2008; Chih et al.,2005; Barrow et al.,2009)...
TOPCONS2 (topcons.cbr.su.se) [59] was used to analyse the amino acid sequences of human CD81 and C. albicans Sur7 and Evp1 to predict their topology and the location of transmembrane (TM) domains. The hydrophobicity plots (light blue chart) and topology diagrams (red and blue lines) ...
submit_example_8.sh- add amino acid bias submit_example_pssm.sh- use PSSM bias when designing sequences Output example: >3HTN, score=1.1705, global_score=1.2045, fixed_chains=['B'], designed_chains=['A', 'C'], model_name=v_48_020, git_hash=015ff820b9b5741ead6ba6795258f35a9c15e94...
amino acids. Once the polypeptide chain has been completed the subsequent folding, post-translational amino acid modifications and protein packaging are all determined by the primary sequence of amino acids. The rate of protein synthesis is controlled by the rate of transcription of specific genes, ...
EMOCPD: Efficient Attention-based Models for Computational Protein Design Using Amino Acid Microenvironment Xiaoqi Ling, Cheng Cai, Demin Kong, Zhisheng Wei, Jing Wu, Lei Wang, Zhaohong Deng arXiv:2410.21069 Mixture of Experts Enable Efficient and Effective Protein Understanding and Design Ning Sun, ...
The NES PylRS charges tRNACUAPyl with the unnatural amino acid (UAA), this charged tRNACUAPyl recognizes the UAG stop codon in the mRNA encoding the POI, and UAA is co-translationally incorporated into the POI. In the subsequent step, a tetrazine derivative of a fluorescent dye reacts ...