SMALL-MOLECULEINTEINSNature - the world's best science and medicine on your desktopdoi:10.1038/nchembio0107-17PerlerFrancine BPubMedNature Chemical BiologyPerler FB.Shining a light on protein expression in living organisms.. Nat Chem Biol . 2007...
Noninvasive imaging of protein-protein interactions in living organisms. Trends Biotechnol 2003;21:241 - 3.Luker, G., Sharma, V., Pica, C., Dahl... GD Luker,V Sharma,D Piwnica-Worms - Humana Press 被引量: 302发表: 2003年 Noninvasive Imaging of Molecular Events with Bioluminescent Reporte...
In this section, we outline the main idea behind CNN-FSRF approach. Figure1gives a schematic diagram of how CNN-FSRF uses convolution neural network and feature-selective rotation forest classifier to predict protein-protein interactions. As can be seen from the figure, our model can be divided...
A wide variety of naturally occurring multidomain fusion proteins have been characterized with different architecture to meet the functional requirements of living organisms at the molecular level (Aroul-Selvam et al., 2004). The modular organization of protein domains observed in natural fusion ...
During the last twenty years much progress has been made in the determination of the molecular structure of living organisms and the understanding of biolo... Pauling,L. - 《Science》 被引量: 390发表: 1961年 Cladogenesis, coalescence and the evolution of the three domains of life In addition...
qRT-PCR is one of the most common tools used to measure gene expression changes in living organisms. We used this technique to determine the gene expression ofskn-1andhsf-1innhr-6RNAi treated worms. It was observed thatnhr-6knock down up-regulated 90-fold and 11-fold the expression ofskn...
All three types of secondary structure (or combinations of secondary structure) can be involved in binding a particular ligand. The immunoglobulin molecule uses a total of six loop structures, three each from the variable domains of the heavy and light chains to bind to an antigen. By a very...
Specialized T cells in the brain found to slow progression of Alzheimer's disease As many as 5.8 million Americans are currently living with Alzheimer's disease, a neurodegenerative condition associated with progressive cognitive decline, including loss of memory capabilities. Protein aggregates, composed...
Thus, the absence of the novel RBPs in previous RBP profiling studies from cultured cells does not result from a lack of expression in these cells. As ex vivo eRIC uses a higher UV dose than previous RIC studies, we addressed whether protein–protein crosslinking contributes “piggy-back ...
The field intensities were selected to span a range between 104 and 107 V m−1 in order to cover both low and moderate intensities that are not incompatible with living organisms and can even exist inside cells38,39. Only for the sake of comparison, we also performed a short ...