We define functional brightness of a given protein as the full-length coverage with annotations of its close homologues, with 0% meaning dark and 100% meaning bright. We first computed the full-length coverage with annotations for all entries in all UniRef50 clusters, and considered a cluster ...
It is estimated that two-thirds of all proteins in higher organisms are composed of multiple domains, many of them containing discontinuous folds. However, to date, most in vitro protein folding studies have focused on small, single-domain proteins. As a
a word derived from the Greekprōteios, meaning “holding first place.” Proteins arespecies-specific; that is, the proteins of one species differ from those of another species. They are alsoorgan-specific; for instance, within a single organism,muscleproteins differ from those of thebrainandlive...
Tryptophan, an amino acid that is nutritionally important and occurs in small amounts in proteins. It is an essential amino acid, meaning that humans and certain other animals cannot synthesize it and must obtain it from their diets. Infants require grea
Whey protein has been well studied and is considered to be a superior protein source for athletes due is its bioavailability and amino acid profile.It is a complete protein with high amounts of essential amino acids,particularly branch-chain amino acids, which are important for muscle repair and...
high-resolution 3D structure of a protein can be assessed using X-ray crystallography [1],NMR spectroscopy[2] or the recent and revolutionary cryo-electron microscopy (cryo-EM) [3].NMRapproaches require appropriateisotopic labellingof the protein and, in case of highmolecular weightsystems and ...
Meaning: If you use these links to buy something, we will not earn a commission. Protein, along with carbohydrates and fats, is one of the three essential macronutrients we need to stay healthy. It supports various body functions, from building and repairing tissues to acting as enzymes, ...
2003. Although little is understood about the cellular and structural meaning of IDPs, they are thought to become ordered only when bound to another molecule (e.g., CREB-CBP complex [Radhakrishnan et al., 1997]) or owing to changes in the biochemical environment Dunker et al. 2001, Dunker...
Heterophilic graphs refer to graphs where linked nodes exhibit heterophily, meaning that they have dissimilar features and different class labels [29]. Many real-world graphs, such as transaction networks [45], exhibit heterophily. Recent studies have shown that GNNs do not perform well on hete...
RNA viruses make up a large fraction of the families present in the dataset, but a smaller fraction of the total proteins (Fig. 1e,f). Structural similarity between viral families with a similar genome type is common, with large dsDNA viruses sharing many protein folds (Extended Data Fig. ...