A connective tissue protein known to support the framework of organs also encourages immune responses that fight bacterial infections, while restraining responses that can be deadly in the condition called sepsis, a new study finds. Ad Led by researchers from NYU Grossman School of Medicine, the wo...
IRF7 controls the production of interferon, an important type of immune protein that fights viruses and bacteria apart from tumour cells "Usually when breast cancer cells leave the breast and travel in the bloodstream and into bone marrow, the release of interferons by IRF7 will cause the immune...
we studied oncogenic potential of both human and sponge R-RAS2 homologs in breast cancer cell line MDA-MB-231. We observed that both proteins increase cell proliferation, number of colonies formed, wound healing and cell migration to a similar extent. ...
The nature of the interactions probed served to understand, in molecular detail, the activation of NHE1 and could serve as input for pharmacomodeling to design a therapeutic drugs that fights lung cancer growth.doi:10.1096/fasebj.30.1_supplement.600.12Daniela Silva...
(Medical Xpress)—Researchers at King's College London have uncovered a protein required by cancer cells to spread to other parts of the body, highlighting it as a potential target for future treatments to prevent secondary cancers (metastases).
acquiring additional mutations that allow them to proliferate and increase the likelihood of cancer129. Thus, a better knowledge of how somatic adult stem cells regulate their proteasome activity may help to understand the origin of cancer stem cells and find specific treatments. Whether proteasome mod...
cancer.91Also, the expression of LAMP-3 surges in tumor cells, which are metastatic in nature.92,93Mujcicet al.94have shown that the PERK/eIF2α/ATF-4 arm of the UPR systemically accentuates LAMP-3 induction under hypoxic conditions. The sustained activation of IRE-1 downstream and ...
The upregulation of proteasomal activity may eliminate these aberrant proteins that otherwise would be toxic for the cell130. Proteasome activity could have an important role in theories that suggest a relationship between the onset of cancer and ageing of somatic stem cells129. During ageing, these...
Simple Summary: The human papillomavirus (HPV), a major carcinogenic pathogen, can cause cervical cancer through persistent infection. The immune system typically fights off the virus, albeit long-term activation may promote carcinogenesis. The micro-immunotherapy medicine 2LPAPI holds promise for aiding...
To create a small molecule protein hydrolysis inducer (SMPI) that targets the ER and METAP2, Zhang et al. [60] combined estradiol/fumagillo with MLAP(OH)YIPM, a short HIF-derived peptide [98]. In lung cancer A549 cells and breast cancer MCF-7 cells, treatments with the above chimeras ...