We isolated a novel full-length human cDNA that encodes a polypeptide with a predicted molecular mass of 21.7 kDa, which binds to the integrin αIIb cytoplasmic domain and is expressed in platelets. The structural properties of CIB indicate that it is a hydrophilic calcium-binding protein, most...
Calmodulin could directly bind to calcium ions as their intracellular recipient, following the Ca2+ influx triggered by alterations on membrane potential. Consequently, the Ca2+-calmodulin complex will stimulate the family of calcium/calmodulin-dependent protein kinase kinases, which consists of calci...
Polymyxin B is a cyclic polycationic peptide antibiotic (Figure 17.3.3) that binds to lipopolysaccharides and anionic lipids. Polymyxin B is also a selective inhibitor of protein kinase C, with an IC50 of ~35 µM, as well as ...
1f). Collectively, our CLIP-seq data and EMSA data indicate that LC3B directly binds to RNA with a preference for the AAUAAA motif. LC3B elicits rapid mRNA degradation in response to autophagic activation What happens when LC3B binds to mRNA? To address this question, we assessed the relative...
(ERRFI; also known as mitogen-inducible gene 6 protein), e.g., which encodes a cytosolic protein that directly binds and inhibits ErbB-family receptors, is deleted in cancer and has shown tumor suppressor activity in experimental cancer models43,44. Our data suggest that RanBP6 possesses ...
In cells, S100A8/A9 relies on calcium ions to bind to specific cytoskeletal components such as microtubules, vimentin, keratin, and actin filaments. With the participation of calcium, S100A8/A9 forms a tetramer that directly binds to the intracellular microtubules and promotes the rapid ...
Gβγ Binds Directly to the G Protein I KACh is an inwardly rectifying potassium channel that plays an important role in the regulation of mammalian heart rate. I KACh is activated by direct interaction with G βγ subunits of pertussis toxin-sensitive heterotrimeric G-pr... 被引量: 33发表...
Ca2+ binds directly the calmodulin domain of CPKs and induces a conformational change resulting in kinase activation [34]. The available information on plant CPKs from various plant species indicates that they are encoded by multigene families and that whereas some of the genes are ubiquitously ...
In summary, the protein ICln directly binds the highly conserved (1020)KVGFFKR(1026) amino acids of the intracellular domain of the integrin αIIb via the (61)ISLHA(65) amino acid motif lying in the β4 - β5 loop and β5 sheet of its pleckstrin-homology-like N-terminal portion. The...
it has been demonstrated that transcription factors form protein–protein interactions with other transcription factors not within the same DNA binding domain family. The most common transcription factor exhibiting this property is Sp1. Sp1 can interact directly with other transcription factors (e.g., ...