Many unannotated microproteins and alternative proteins (alt-proteins) are coencoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing regulated synthesis could play important cellular
Summary diagram of the cargo and surface composition of MVs from isotype or CD24 stimulated cells. The differences in surface protein, luminal protein, and RNA transcriptome between basal and CD24 induced MVs are shown. No change indicated by=, absence indicated by X, a significant change indica...
(VPGVG)nis the most widely used and studied structural feature for the synthesis of different ELR compositions. Further examples of elastomeric series present in natural elastin that can be incorporated on ELRs include otherpentapeptides(e.g.,IPGVG),heptapeptides(e.g.,LGAGGAG), andnonapeptide...
This acidic portion of proMBP may serve to protect cellular structures from its cytotoxic activities during synthesis and packaging. The larger proMBP, however, has been identified in immature bone marrow cells. proMBP has also been found in placental cells in complex with the metalloproteinase ...
基因导致蛋白质合成(Genescauseproteinsynthesis) Teachingdesignofproteinsynthesisguidedby4.1gene 1.teachingfocus (1)understandtheintermediatesubstanceofgenecontrolled proteinsynthesis-thebasicunit,chemicalcompositionand speciesofRNA,anditssimilaritiesanddifferencesin composition,structure,functionanddistributionofDNA; (2)...
Figure 1:We represent the protein ribbon diagram on the left by a flexible underlying topological structure, shown on the right.In Section 2, we present a survey of non-planar topological structures that have been previously identifiedwithin proteins. Then in Section 3, we present new examples ...
a.Venn diagram overview [38] of the number of protein identities detected in oocytes and preimplantation stages of the mouse following LC-MS/MS.b.Distribution of individual protein abundances (riBAQ) in oocytes and blastocysts.c.Survey of the top 50 most abundant proteins detected in oocytes, ...
Expression levels for the two Solexa-based sequencing-by-synthesis methods we used, Solexa dual-tag-based (STB) and Solexa whole transcriptome (SWT)http://www.illumina.com/technology/sequencing_technology.ilmn), are also reported in transcripts per 10 million and derived from experiments on pooled...
Semi-synthesis of GFP in HEK cells The above data showed that tPTS could be used to insert synthetic peptides into large membrane proteins in live eukaryotic cells, but it was important to demonstrate delivery into mammalian cells, which can be more challenging. To demonstrate the feasibility of...
performed the chemical synthesis; S.-Q.L. helped with data analysis and interpretation, revised the manuscript; K.Y. helped with data analysis and interpretation. Corresponding authors Correspondence to Chun Tang, Meng-Qiu Dong or Xiaoguang Lei. Ethics declarations Competing interests The authors ...