The fusion protein or polypeptide of the present disclosure can also be produced by chemical synthesis (e.g., by the methods described in Solid Phase Peptide Synthesis, 2nd ed., 1984, The Pierce Chemical Co., Rockford, Ill.). Modifications to the protein can also be produced by chemical sy...
This enzyme is activated as a result of the alterations in cellular energy levels [3]. The activation of AMPK also exerts long-term effects at the level of both gene expression and protein synthesis, such as positive effects on glucose uptake of heart, food intake of hypothalamus, and ...
A previous screening of the target genes of SyCRP1 in PCC6803 using microarray showed that 18 genes in 13 putative TUs were down-regulated in asycrp1disruptant compared with the wild type strain [25]. Our preliminary manual scanning of the upstream promoter regions of these TUs revealed that ...
Such inhibitory peptides may be chemically synthesized using known peptide synthesis methodology or may be prepared and purified using recombinant technology. Such peptides are usually at least about 5 amino acids in length, but can be anywhere from 5 to 100 amino acids in length. Such peptides...
Furthermore, overexpression of NF-κB/p65 did not alter the synthesis and maturation of APP695 (data not shown), and the κB sites of APP gene interact with NF-κB/p50 but not NF-κB/p65 (18). The observations suggest the significance that NF-κB signaling system connects to Aβ42 ...
NEP1-like proteins (NLPs) are a novel family of microbial elicitors of plant necrosis. Some NLPs induce a hypersensitive-like response in dicot plants though the basis for this response remains unclear. In addition, the spatial structure and the role of
The basal interaction k in equation (1) represents unknown protein-protein interactions that result from other possible interacting proteins or other influences (e.g., mRNA-protein interactions, protein synthesis). ε[t] represents random noise arising from model uncertainty and molecular fluctuations ...
PPP1CB is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. PP1 inhibits the synthesis of proteins involved ...
Furthermore, a number of transcriptional changes were identified which correlate with the gradual aggregation of polyQ-expanded ATXN1 in human SCA1 cerebellum, as well. These include dysregulation of the protein synthesis machinery and pathways involved in focal adhesion or oxidative phosphorylation [20...