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cover.jpg update style Apr 29, 2023 Repository files navigation README Code of conduct GPL-3.0 license List of papers about Protein Design using Deep Learning This repository is inspired by the remarkable work of Kevin Kaichuang Yang and their outstanding project Machine-learning-for-proteins. We ...
Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence similarity to previously annotated proteins. We develop two deep learning methods to address this gap, TM-Vec a
P. Advanced glycation end-products: a biological consequence of lifestyle contributing to cancer disparity. Cancer Res. 75, 1925–1929 (2015). 36. Sun, S. S. M. & Liu, Q. Transgenic approaches to improve the nutritional quality of plant proteins. In Vitro Cell Dev. Biol. – Plant, 40...
5Wang, W., G. Haberer, H. Gundlach, C. Gläßer, T. Nussbaumer, M. C. Luo, A. Lomsadze, et al. “The Spirodela Polyrhiza Genome Reveals Insights into Its Neotenous Reduction Fast Growth and Aquatic Lifestyle.” Nature Communications 5 (2014): 3311. doi:10.1038/ncomms4311. ...
These different mRNAs in turn translate into alternate versions of proteins that can perform various functions. The researchers generated two different, alternatively spliced teneurins and tested their functionality. It turned out that just a tiny discrepancy or seven out of 2,500 amino acids made a...
Notice that \({{{\mathbf{x}}}^{(k)}\in {{\mathbb{R}}}^{L\times {d}_{\mathrm{PLM}}}\) is the representation of the amino-acid sequence. We then apply the widely used Transformer-style blocks4 to process the embedding vectors, denoted by $${{{\mathbf{x}}}^{(k+1)}={\ma...
(AviTag) were also expressed in the presence of a BirA enzyme, resulting in spontaneous biotinylation during protein expression. Expi293F cells were cultured in media containing 66% FreeStyle/33% Expi media (Thermo Fisher Scientific) and grown in TriForest polycarbonate shaking flasks at 37 ...