To detect homologous proteins with remote similarity, the (PS)2-v2 server utilizes the S2A2 matrix, which is a 60 × 60 substitution matrix using the secondary structure propensities of 20 amino acids, and the position-specific sequence profile (PSSM) generated by PSI-BLAST. In addition, our ...
The trRosetta (transform-restrained Rosetta) server is a web-based platform for fast and accurate protein structure prediction, powered by deep learning and Rosetta. With the input of a protein’s amino acid sequence, a deep neural network is first used to predict the inter-residue geometries, ...
Protein structure prediction on the Web - a case study using the Phyre server 热度: Resampling Methods for Protein Structure Prediction 热度: SCRATCH:aproteinstructureandstructuralfeature predictionserver J.Cheng,A.Z.Randall,M.J.SweredoskiandP.Baldi* ...
The PSIPRED protein structure prediction server allows users to submit a protein sequence, perform a prediction of their choice and receive the results of the prediction both textually via e-mail and graphically via the web. The user may select one of three prediction methods to apply to their...
In protein docking we aim to find the structure of the complex formed when two proteins interact. Protein–protein interactions are crucial for cell function. Here we discuss the usage of DOCK/PIERR. In DOCK/PIERR, a uniformly discrete sampling of orient
structurepredictionserverwhichprovides predictionsbytheJNetalgorithm,oneofthemostac- curatemethodsforsecondarystructureprediction. Inadditiontoproteinsecondarystructure,JPred alsomakespredictionsofsolventaccessibilityand coiled-coilregions.TheJPredservicerunsupto94 000jobspermonthandhascarriedoutover1.5mil- lionprediction...
The community-wide Critical Assessment of Structure Prediction (CASP) experiments have been designed to obtain an objective assessment of the state-of-the-art of the field, where I-TASSER was ranked as the best method in the server section of the recent 7th CASP experiment. Our laboratory ...
Determining the structure and function of a novel protein is a cornerstone of many aspects of modern biology. Over the past decades, a number of computational tools for structure prediction have been developed. It is critical that the biological communit
The I-TASSER structure prediction server as well as its function annotation components COFACTOR and COACH have all been objectively evaluated in the CASP and CAMEO structure and function prediction challenges, in which these programs showed considerably higher performance when compared with other state-...
I-TASSER: Fully automated protein structure prediction in CASP8 The I-TASSER algorithm for 3D protein structure prediction was tested in CASP8, with the procedure fully automated in both the Server and Human sections. T... Yang,Zhang - 《Proteins Structure Function & Bioinformatics》 被引量: ...