Protein tertiary structure prediction is a fundamental problem in computational biology and identifying the most native-like model from a set of predicted models is a key sub-problem. Consensus methods work well when the redundant models in the set are the most native-like, but fail when the mo...
What is a globular protein in biology? A protein in which at least one polypeptide chain is folded in a three-dimensional configuration. ... Globular proteins have a variety of functions (e.g. acting as enzymes, facilitating transport, and providing storage)....
Several approaches for use in rational drug design include analysis of three-dimensional structure, alanine scans, molecular modeling and use of anti-id antibodies. These techniques are well known to those skilled in the art. Following identification of a substance which modulates or affects polypept...
Many proposed statistical measures can efficiently compare protein sequence to further infer protein structure, function and evolutionary information. They share the same idea of usingk-word frequencies of protein sequences. Given a protein sequence, the information on its related protein sequences hasn'...
NEP1-like proteins (NLPs) are a novel family of microbial elicitors of plant necrosis. Some NLPs induce a hypersensitive-like response in dicot plants though the basis for this response remains unclear. In addition, the spatial structure and the role of
cytokine release, degranulation, tyrosine phosphorylation, ion (e.g., calcium) flux, metabolic activity, apoptosis, changes in gene expression, maintenance of cell structure, cell migration, adherence to a substrate, signal transduction, cell-cell interactions, and others described herein or known in...
The construction, spectroscopic analysis and x-ray crystal structure of the mutant AM260W have been described in detail 30., 31., 32.. The QA ubiquinone was removed chemically from R26 RCs using a procedure described previously (33) as modified by Woodbury et al. (34). For the vis/mid-...
a, structure of human X11L and NF-κB/p65. PI, phosphotyrosine interaction domain; PDZ, PDZ domain; RHD, Rel homology domain; NLS, nuclear localization signal; TA, transcription activation domain. Numbers refer to amino acid positions. b, yeast two-hybrid assays with NF-κB/p65 and PDZ do...
Proteins localized at different submitochondria locations have different N-terminal or C-terminal targeting signal peptides. Andrade, et al. [5] have pointed out that at the subcellular level, the average physicochemical properties of a protein molecular surface are adapted to the micro environment ...
Cyclic AMP receptor protein (CRP), also known as catabolite gene activator protein (CAP), is an important transcriptional regulator widely distributed in many bacteria. The biological processes under the regulation of CRP are highly diverse among differe