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We implemented our algorithm using a cell-linked-lists data structure to store the positions of FG-nups particles, achieving O(N) computational complexity, where N is the total number of voxels. Connectivity analysis Results from the aforementioned void analysis were applied to perform connectivity ...
Propeptides perform a dual function: promoting the correct folding of the protease domain and blocking its proteolytic activity while within the cell, prior to delivery to the secretion machinery. Because this function exactly corresponds to the role of chaperones, such propeptides are often termed...
with rabies virus glycoprotein (RVG) peptides, which specifically bind to nicotinic acetylcholine receptors expressed in the brain, exhibit effective central nervous system (CNS)-targeted delivery [28]. mRNA-based therapeutics are recognized as a viable strategy for precision medicine [29]. EVs have ...
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Depletion of membrane fusion machinery Trs20, Rab1, Rint1, Syx5 or Bet1 did not affect the LD delivery of cytosolic cargoes Lsd1, CGI-58 or CCT1 (Fig. 3d,e and Extended Data Fig. 5f,g), indicating that it specifically affected ER-to-LD targeting. The targeting phenotype was specific...
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The small pop-and mom shops actually did rather well in this mayhem. They adapted quickly to ensure social distancing. They took orders for pick up and for delivery, and actually prepared them without errors. Most of all, they showed no disruption of supplies. The small meat store had meat...
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