drug formulation and storage. Biotherapeutic drugs can be analysed at their subunit level following reduction and/or digestion. Analysis of therapeutic antibody subunits facilitates exact molecular weight analysis of their heavy and light chains and...
Current protein design models can natively handle multiple protein chains in their inputs, allowing them to design the sequences of interacting proteins. However, they only poorly handle non-protein entities within the design process, which hampers their versatility and limits their scope of applicabil...
The ability to design functional sequences and predict effects of variation is central to protein engineering and biotherapeutics. State-of-art computational methods rely on models that leverage evolutionary information but are inadequate for important applications where multiple sequence alignments are not ...
aA schematic overview of Hamiltonian mapping of VAE latent space and its applications. Using a multiple sequence alignment as input, DCA and VAE models are independently trained. Maximum probability grid-sampled sequences (S*) from the VAE latent space are then scored by DCA with a Hamiltonian v...
A major challenge in protein design is to augment existing functional proteins with multiple property enhancements. Altering several properties likely necessitates numerous primary sequence changes, and novel methods are needed to accurately predict comb
drug formulation and storage. Biotherapeutic drugs can be analysed at their subunit level following reduction and/or digestion. Analysis of therapeutic antibody subunits facilitates exact molecular weight analysis of their heavy and light chains and ...
Publishes research papers and review articles relevant to the engineering, design and selection of proteins for use in biotechnology and therapy, and for
Protein design and structure solution for drug discovery [Crystallography Reviews (2024)] Design of Protein Sequences with Precisely Tuned Kinetic Properties [bioRxiv 2025.02.13.638027] 0) Benchmarks and datasets Sequence dataset/benchmarks • Structure datasets/benchmarks • Public database...
6.4.2 Prediction of protein secondary structure from the amino acid sequence The local structure that is formed by a protein's polypeptide backbone is referred to as the protein's secondary structure. The -helix (H), the -strand (E), and the coil (C) area are the three different kinds...
If Biopython is installed, BRAKER can generate FASTA-files with coding sequences and protein sequences predicted by AUGUSTUS and generate track data hubs for visualization of a BRAKER run with MakeHub R16. These are optional steps. The first can be disabled with the command-line flag --skipGet...