Further, we described the involvement of S-sulfhydration in different biological and cellular functions, such as inflammatory response, mitochondrial integrity, calcium imbalance, and oxidative stress. Moreover, we highlighted the importance of S-sulfhydration in cerebrovascular and neurodegenerative diseases....
Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration. FASEB J. 2016;30(1):441-56.S. Saha, P. K. Chakraborty, X. Xiong et al., "Cystathionine β-synthase regulates endothelial function via protein S- sulfhydration," The FASEB Journal, vol. 30, no. 1, pp. ...
Protein S-persulfidation (P-SSH) is recognized as a common posttranslational modification. It occurs under basal conditions and is often observed to be elevated under stress conditions. However, the mechanism(s) by which proteins are persulfidated inside cells have remained unclear. Here we repo...
Zivanovic, J. et al. Selective persulfide detection reveals evolutionarily conserved antiaging effects of s-sulfhydration.Cell Metab.30, 1152–1170.e13 (2019). ArticleCASPubMedPubMed CentralGoogle Scholar Gao, X.-H. et al. Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming...
Moreover, different redox states of sulfur-containing amino acids result in various Cys oxidized PTMs (Ox-PTMs) including S-glutathionylation (RSSG), disufide bond formation (S-S), sulfenylamide (-SN), S-sulfhydration (-SSH), sulfenylation (-SOH), sulfinylation (-SO2H), and ...
The range of PTMs includes phosphorylation, acetylation, methylation, ubiquitination, SUMOylation, neddylation, glycosylation, palmitoylation, myristoylation, prenylation, cholesterylation, glutathionylation, S-nitrosylation, sulfhydration, citrullination, ADP ribosylation, and several novel PTMs. Here, we ...
S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis. Pharmacol Res. 2023;192:106788. Article CAS PubMed Google Scholar Stolzing A, Jones E, McGonagle D, Scutt A. Age-related changes in human bone marrow-...
Pain Medicine, University of Washington, Seattle, USAA R T I C L E I N F OKeywords:Hydrogen Sulf i deMitochondriaHeart FailureCa 2+ /calmodulin-dependent protein kinase IIS-sulfhydrationA B S T R A C TAims: Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) plays a critical role...
parkin E3 ligase activity was shown to be increased by both sulfhydration (Vandiver et al., 2013) andneddylation, the covalent linkage of ubiquitin-likeNEDD8 protein(Choo et al., 2012;Um et al., 2012). Parkin sulfhydration was reduced in brain samples from PD patientsversuscontrol samples (...
Finally, parkin E3 ligase activity was shown to be increased by both sulfhydration (Vandiver et al., 2013) and neddylation, the covalent linkage of ubiquitin-like NEDD8 protein (Choo et al., 2012; Um et al., 2012). Parkin sulfhydration was reduced in brain samples from PD patient...