5h,i), a step that may be required for the membrane-RNA recruitment to granules. Fig. 5: Analysis of the characteristics driving RNAs to granules. a, Distributions for changes in granule proportions upon UPR activation for lncRNA and mRNAs. Results from a two-sample Kolmogorov–Smirnov (K...
Predictions of side-chainχangles as well as the final, per-residue accuracy of the structure (pLDDT) are computed with small per-residue networks on the final activations at the end of the network. The estimate of the TM-score (pTM) is obtained from a pairwise error prediction that is ...
Besides the transcriptional induction of adaptive functions, cells also need to (partially) shut down unnecessary cellular functions that are not required for the new state. To do this, cells could first reduce the transcript levels (Brauer et al., 2008, Lee et al., 2011, Marguerat et al....
These skn-1(mg672) mutants show defective activation of rpt-3p::gfp following bortezomib treatment, consistent with our previous finding that proteolytic cleavage of SKN-1A is required for activation of the proteasome reporter (Lehrbach and Ruvkun, 2016) (Figure 1G). Thus, proteolytic cleavage ...
albicans EVs but antibody-based validation is required. Following in vitro validation, these markers will enable the use of a plethora of EV analysis methods, which have not yet been applied to fungal EVs due to the absence of protein markers. Examples include EV immunocapture, in vitro ...
Thus, proteins of the protein secretion machinery detected by proteomics and the 16 genes of protein secretion machinery which had a correlation to SPPR > 0.7 may highlight key activities of protein secretion machinery which are required for especially high level of protein secretion. Primary ...
elegans CLIC-like protein required for intracellular tube formation and maintenance. Science. 2003, 302 (5653): 2134-2137. Article CAS Google Scholar Chalothorn D, Zhang H, Smith JE, Edwards JC, Faber JE: Chloride intracellular channel-4 is a determinant of native collateral formation in ...
has been reported that PP2As are required for asymmetric auxin distribution in seedling roots of Arabidopsis [43]. During male and female inflorescence differentiation and kernel development, the transcripts of ZmPIN gene were showed to have overlapping expression domain in the root apex [44]. More...
et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15, 675–690 (2012). Article PubMed PubMed Central CAS Google Scholar Canto, C. et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 act...
Interestingly, oral tolerance to ovalbumin could not be induced in a mouse model in which nTregs but not iTregs could be generated, suggesting that this model required peripheral conversion of naive CD4 T cells into iTregs.72 This observation is consistent with the findings described above ...