Intercellular protein-protein interactions at synapses. Protein & cell 5, 420-444 (2014).Yang X, Hou D, Jiang W, Zhang C (2014) Intercellular protein-protein in- teractions at synapses. Protein Cell 5:420 - 444. CrossRef MedlineX. Yang, D. Hou, W. Jiang, and C. Zhang, "...
These findings demonstrate a novel mechanism regulating presynaptic activity and synapse elimination during development, and suggest that protein translation acts coordinately with activity to selectively stabilize appropriate synaptic interactions. 展开 关键词:...
Intercellular protein–protein interactions (PPIs) enable communication between cells in diverse biological processes, including cell proliferation, immune responses, infection, and synaptic transmission, but they are challenging to visualize because existing techniques123have insufficient sensitivity and/or specif...
Localization of the presynaptic cytomatrix protein Piccolo at ribbon and conventional synapses in the rat retina: Comparison with Bassoon In recent years significant progress has been made in the elucidation of the molecular assembly of the postsynaptic density at synapses, whereas little is ... O ...
(Hirst et al., 2016), and further studies will clarify both the clinical presentation and functional role of these interactions. Along these lines, mutations in multiple proteins of the AP-4 adaptorprotein complex, involved in trafficking ofamyloid precursor proteinfrom thetrans-Golgi to endosomes ...
Multiple and hierarchical phosphorylations.Multiple phosphorylations by different protein kinases on the same enzyme are relatively frequent and may lead to interesting interactions, such as sequential and hierarchical phosphorylation. A classical example is glycogen synthase, in which nine different phosphoryl...
Parasitic fungi produce proteins that modulate virulence, alter host physiology, and trigger host responses. These proteins, classified as a type of “effector,” often act via protein–protein interactions (PPIs). The fungal parasite Ophiocordyceps camp
both peaks had trailing and leading shoulders suggesting the presence of low abundance oligomers intermediate in size between Aβ monomer and the void material. Given the limited size resolution of SEC, and the possibility of forming artefacts owing to non-ideal interactions with the column, we als...
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neurexins and neuroligins provide trans-synaptic connectivity by the Ca 2+-dependent interaction of their alternatively spliced extracellular domains. Neur... Demet Ara...
Many endocytic proteins accumulate in the reserve pool of synaptic vesicles (SVs) in synapses and relocalize to the endocytic periactive zone during neurotransmitter release. Currently little is known about their functions outside the periactive zone. Here we show that in the Drosophila neuromuscular...