NMDARs are expressed at high levels, are widely distributed throughout the brain, and are involved in several physiological and pathological conditions. Here, we will focus on the GluN2A- and GluN2B-containing
The appropriate formation of synapses, both spatially and temporally, is essential for brain function and depends on the intercellular protein-protein interactions of cell adhesion molecules (CAMs) at synaptic clefts. The CAM proteins link pre- and post-synaptic sites, and play essential roles in ...
The appropriate formation of synapses, both spatially and temporally, is essential for brain function and depends on the intercellular protein-protein interactions of cell adhesion molecules (CAMs) at synaptic clefts. The CAM proteins link pre- and post-synaptic sites, and play essential roles in ...
Designer nanodiscs to probe and reprogram membrane biology in synapses J Mol Biol (2022), p. 167757 Google Scholar 5 M. Xue, Y. Cao, C. Shen, W. Guo Computational advances of protein/neurotransmitter-membrane interactions involved in vesicle fusion and neurotransmitter release J Mol Biol (2022...
Synapses can be detected with high sensitivity by a split reporter that visualizes intercellular protein–protein interactions. Intercellular protein–protein interactions (PPIs) enable communication between cells in diverse biological processes, includi
In so doing, they suggest that the cytoplasmic domain of MHCI could participate in previously unsuspected PDZ mediated protein-protein interactions at neuronal as well as immunological synapses. The online version of this article (doi:10.1186/s12865-016-0154-z) contains supplementary material, which...
Parasitic fungi produce proteins that modulate virulence, alter host physiology, and trigger host responses. These proteins, classified as a type of “effector,” often act via protein–protein interactions (PPIs). The fungal parasite Ophiocordyceps camp
both peaks had trailing and leading shoulders suggesting the presence of low abundance oligomers intermediate in size between Aβ monomer and the void material. Given the limited size resolution of SEC, and the possibility of forming artefacts owing to non-ideal interactions with the column, we als...
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and accounts for more than 60–80% of all cases of dementia. Loss of pyramidal neurons, extracellular amyloid beta (Abeta) accumulated senile plaques, and neurofibrillary tangles tha
Protein trafficking, targeting, and interaction at the glutamate synapse N-terminal GluR2 interactions The NTD showssequence homologyto theleucine,isoleucine, valine-binding protein LIVBP, one of the bacterialperiplasmic binding proteins(PBPs) (O'Hara et al., 1993). The function ascribed to the NTD...