Ludlow, Protein phosphatase type 1, the product of the retinoblastoma susceptibility gene, and cell cycle control, Front. Biosci. 3 (1998) D1209-D1219.Rubin, E., Tamrakar, S. y Ludlow, J. W. (1998). Protein phosphatase type 1, the product of the retinoblastoma susceptibility gene, and...
Protein Phosphatase 1 (PP1) is a major serine/threonine phosphatase in eukaryotes, participating in several cellular processes and metabolic pathways. Due to their low substrate specificity, PP1’s catalytic subunits do not exist as free entities but instead bind to Regulatory Interactors of Protein ...
Germ-cell proliferation and differentiation is tightly regulated by reversible protein phosphorylation9. While the role of various protein kinases has already been firmly established very little is known about the counteracting phosphatases. Protein phosphatase 1 (PP1) catalyzes a major fraction of phospho...
(e.g., PP1, PP2A, and PP2B) are multimeric protein complexes consisting of a catalytic subunit and one or two accessory or regulatory subunits. These accessory proteins can confer a variety of effects to the protein complex, such as substrate specificity, modulation of phosphatase activity or ...
We and others have reported recently (30, 31) the cloning and initial characterization of a novel nuclear PP1-binding protein named PNUTS (Phosphatase 1 NUclear TargetingSubunit) or p99. PNUTS exhibits a discrete nuclear compartmentalization and is found in a stable complex with PP1 in mammalian...
Protein tyrosine kinase PTP: Protein tyrosine phosphatase RA: Retinoic acid RTK: Receptor tyrosine kinase TMA: Tissue microarray References Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. 2007;369(9579):2106–20. Article CAS PubMed Google Scholar Matthay KK, Maris JM...
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell. 2006;23:757–64. Article CAS PubMed Google Scholar Peng A, Lewellyn AL, Schiemann WP, Maller JL. Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. Curr Biol. 2010;20:387–...
groups changes within a small range, mostly from 1 to 3. In rice, similar results of gene structure analysis were given in Additional file5, indicating that similar intron loss or gain events occurred during expansion and structural evolution of 2C-type protein phosphatase may exist in mono...
The protein bands were visualized by ECL (Amersham Biosciences) or alkaline phosphatase reaction (New England Biolabs) and quantitated by densitometric scanning using Scion Image software (Scion Corporation). GFP-coimmunoprecipitation and immunoblotting For the GFP-coimmunoprecipitation assays, COS-1 ...
(Cohen, 1997). Purifiedphosphatase proteins 1, 2A, and 2B can dephosphorylate tau proteins (Goedertet al.,1992a;Fleming and Johnson, 1995;Goedertet al.,1995). Like kinases, phosphatases have many direct or indirect physiological effects and counterbalance the action of kinases.Phosphatasesacting ...