In HSV-1-infected cells, the neurovirulence factor γ34.5 is mainly responsible for keeping eIF2α dephosphorylated [100]. The C-terminus of γ34.5 has a primary structure similar to the C-terminal domain of GADD34 [101]. This γ34.5 region contains a validated RVxF motif (HSV-1:192RVR...
Protein Phosphatase 1 (PP1) is a major serine/threonine phosphatase in eukaryotes, participating in several cellular processes and metabolic pathways. Due to their low substrate specificity, PP1’s catalytic subunits do not exist as free entities but ins
Int. J. Pept. Protein Res., 42 (1993), pp. 44-52 CrossrefView in ScopusGoogle Scholar [34] M.C. Morris, L. Chaloin, M. Choob, J. Archdeacon, F. Heitz, G. Divita The combination of a new generation of PNAs with a peptide-based carrier enables efficient targeting of cell cycle...
Protein Pept. Lett., 19 (2012), pp. 761-769 CrossrefView in ScopusGoogle Scholar [119] Z. Dauter, M. Jaskolski, A. Wlodawer Impact of synchrotron radiation on macromolecular crystallography: a personal view J. Synchrotron Radiat., 17 (2010), pp. 433-444 View in ScopusGoogle Scholar [...
Milk proteins and milk protein-derived peptides have been widely studied for their health enhancing properties. This chapter presents the updated scientific knowledge on the bioactive properties of milk protein-derived peptides. The different bioactive p
Protein Pept Lett. 2009;16:486–9. Article CAS PubMed Google Scholar Siva AB, Kameshwari DB, Singh V, Pavani K, Sundaram CS, Rangaraj N, et al. Proteomics-based study on asthenozoospermia: differential expression of proteasome alpha complex. Mol Hum Reprod. 2010;16:452–62. Article...
Campen, A.et al.TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder.Protein Pept. Lett.15, 956–963 (2008). CASPubMedPubMed CentralGoogle Scholar Linding, R., Russell, R. B., Neduva, V. & Gibson, T. J. GlobPlot: exploring protein sequences for globul...
Peptides and proteins are widely used to treat a range of medical conditions; however, they often have to be injected and their effects are short-lived. These shortcomings of the native structure can be addressed by molecular engineering, but this is a c
Alzheimer’s disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ) peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary tangles. Extensive research has focused on understanding the asse
Protein Pept Lett. 2017;24(3):253–66. https://doi.org/10.2174/0929866523666161213094936. Article CAS PubMed Google Scholar Wind M, Lehmann WD. Element and molecular mass spectrometry—an emerging analytical dream team in the life sciences. J Anal At Spectrom. 2004;19(1):20–5. https:/...