protein nitrosylationBerkeley Electronic Press Selected WorksSusan Rey
网络释义 1. 蛋白质巯基亚硝基化 ...O),改变蛋白质构象及蛋白质功能,这一作用被定义为蛋白质巯基亚硝基化(protein S-nitrosylation)。 cdmd.cnki.com.cn|基于 1 个网页
Levels of protein-glutathione mixed disulfides appeared to be inversely related to S-nitrosylation but changes across groups were not statistically-significant. In addition, unique challenges to the trapping of the in vivo redox states of protein vicinal thiols and the determination of the effects of...
泛素化过程通常需要3种泛素化酶的协同作用: ①在ATP供给能量的情况下,泛素激活酶E1将泛素分子活化;② 泛素激活酶E1将活化的泛素分子传递给泛素结合酶E2;③ 泛素连接酶E3将结合E2的泛素连接到靶蛋白上。 四、亚硝基化 S-nitrosylation 指一氧化氮 (nitric oxide, NO) 及其衍生物修饰蛋白质半胱氨酸 (cysteine, Cy...
NitrosylationNO (nitric oxide)-mediated protein-nitrosylation has been established as one major signaling mechanism underlying cancer initiation and development, but its roles in PDAC (pancreatic ductal adenocarcinoma) pathogenesis still remain largely unexplored. In this study, we identified 585 unique...
Protein denitrosylation, the removal of nitric oxide groups from Cys thiols, was once considered to be a spontaneous event. Now, the discovery of denitrosylases, the enzymes that catalyse this process, is advancing our understanding of redox-based signal
In recent years, a variety of proteins in human body have been found to undergo thiol nitrosylation under specific conditions. Protein SNO, which is closely related to cardiovascular disease, Parkinson's syndrome, Alzheimer's disease and tumors, plays an important role in regulatory mechanism of ...
S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain of cysteine, has emerged as an important mechanism for dynamic, post-translational regulation of most or all main classes of protein. S-nitrosylation thereby co
S‐Nitrosylation, the redox‐based modification of cysteine thiol side chains by nitric oxide, is a dynamic and reversible post‐translational modification of proteins that subserves many important cellular functions. Analysis of protein S‐nitrosylation is often challenging due to methodological ...
In this context, the gas transmitter nitric oxide may act through several mechanisms, such as guanylyl cyclase activation and via S-nitrosylation of proteins. The latter is a covalent modification of a protein cysteine thiol by a nitric oxide-group that generates an S-nitrosothiol. Here, we ...