However, well-designed, randomized clinical trials are needed to clearly define the protein doses and amino acid composition (i.e., amount of leucine) that can provide the maximal health and functional benefits in critically ill geriatric patients. Specifically, it will be important to test ...
In combination, these data indicate that lactating women should aim to consume at least 1.7 g/kg/d, but further evidence is needed to define the optimal daily protein intake in this population, and to investigate how carrying more than one child may alter this value....
354 proteins with sex-biased expression identified in the current work (Supplementary Table16). Moreover, we found that 25% of the causal genes in brain traits, on average, had sex-biased protein expression (range 5–50%; Fig.3a). Further...
women on the soy-nut diet: –5.2% and –2.9% for SBP and DBP, respectively. However, other dietary changes possibly contributed to the BP- lowering effect observed in this studyas participants were not following their habitual diets. Further research is needed, as this was the first clinical...
Future work will be needed to further illustrate the functional mechanism of GBD-9. As both PROTACs and molecular glues have strength and limitation, it will be excited to see more examples that can harness the strength of both strategies. Fig. 5 Schematic representation of a double-mechanism ...
Encouraging all women, but especially older women, to consume more protein may help to extend independent living and quality of life with aging, but randomized trials are needed to establish causality. Acknowledgments None. Funding Sources: None. Conflicts of Interest: The authors report no ...
This randomized clinical trial investigates whether greater than the recommended dietary allowance of protein is needed to maintain lean body mass in
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently
($5 g/day) in women over 35 years, was associated with a greatly increased probability of adverse maternal and fetal outcomes Spot urine P/C ratio between 30–35 mg/mmol (0.30–0.35 mg/mg) is an optimal threshold value to detect proteinuria >0.3 g/day Spot urine P/C ratio was highly...
56, 57 Additional clinical studies are needed to determine whether both feeding patterns are effective or whether one is clearly favored over the other. Such strategies should be tested in both long- and short-term clinical interventions. Specific Recommendations on Dietary Protein Intake by Healthy ...