extracellularly (Fig.1C, lower panel). Double-labelling experiments with 5B2 and 6D11 corroborate these phenotypic differences. Whilst both antibodies colabelled PrPdaggregates at the plasma membrane, 5B2 failed to detect perinuclear PrPd(Fig.1D). In uninfected control cells, both antibodies weakly...
a The process of KRAS localization to the plasma membrane. b The chemical structures of inhibitors of KRAS/PDEδ Full size image There are many small molecule compounds that inhibit the interaction between PDEδ and KRAS.137,141,142,143,144,145,146 In 2018, Chen et al.147 discovered the ...
1f), as fusion approached a plateau (days 4, 5), La gradually shifted to a predominantly nuclear localization in osteoclasts (Fig. 1g). We found that this change in localization of La correlates with its phosphorylation status. Most La in human cells is phosphorylated at Ser 366 and ...
There are several mechanisms for delivering proteins to their final destination: signal sequences for secreted proteins, mannose phosphate tagging for lysosomal enzymes, translocase presequences for mitochondrial proteins, and nuclear localization sequences for nuclear proteins. Secreted Proteins A signal ...
and movement of tissues along a plane. These changes are primarily thought to occur through changes in protein levels and localization rather than transcriptional regulation (Adler, 2012;Schlessinger, Hall, & Tolwinski, 2009). Additionally, BCI receptors have been implicated inHSCrepopulation (Famili...
to rationalize that process to a greater extend. One way bioinformatics can support assay development at this stage is through the localization of the distinct area on the protein target, also referred to as the antigen, that the antibody will bind to. This area is called theepitopeand can ...
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear ...
In the present study, we integrated cis-pQTL data for a proteome-wide MR analysis to identify PC-associated plasma proteins. Bidirectional MR, replicative validation and meta-analysis, and Bayesian colocalization were used to confirm the primary results. Then the corresponding protein-coding gene exp...
We therefore consider the performance of protein language models in four sequence annotation tasks where it was possible to recover the original codon sequence (Methods): melting point prediction, solubility prediction, subcellular localization prediction and function prediction. These datasets are described...
Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies (MVBs), mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs. However, the molecular mechanism by which proteins are sorted to sEVs is n