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DNA-recognition in a genome towards gene expression requires rapid binding of modifying enzymes, polymerases, repressors and activators to their site of action on a large, packaged DNA, not always easily “visible” to the acting proteins (Gasser and Laemmli, 1987). The interaction between a ...
The high expression of PD-L1 preferentially binds to PD-1 on CD8 + T cells, prompting tumor cells to escape from immune cell attack. In addition, HIF-1α accelerates the progression of macrophages and tumor cells. In addition to its role in tumor progression, inflammation also affects the ...
Yang A, Schweitzer R, Sun D et al (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398:714–718 Article CAS PubMed Google Scholar Hall PA, Campbell SJ, O’Neill M et al (2000) The expression of the p53 homologue, p63α and...
282,283 5-HT receptors 1 and 2 are the most intensively studied drug targets. The receptors have various effects with multiple subtypes and alternative splice variants. 5-HT1 and 5-HT2 receptors have different expression patterns in the brain with similar or opposite functions.284 5-HT1 ...
The protein expression of p63 (mainly DNp63a isoform) is negatively correlated with the expression of WWP1 in all these cell lines. The only exception is 22Rv1, in which the expression of WWP1 is not increased but p63 is still undetectable. Similar results are obtained in 10 breast cancer...
Temporal regulation of late expression of Bar homeobox genes during Drosophila leg development by Spineless, a homolog of the mammalian dioxin receptor The ta5 enhancer was comprised of a basal enhancer required for driving Bar expression and a negative regulatory motif serving as a binding site for...
The direct target of Ihh signaling is the perichondrium, where Gli and Ptc flank the expression domain of Ihh. Ihh induces the expression of a second signal, parathyroid hormone-related protein (PTHrP), in the periarticular perichondrium. Analysis of PTHrP ...
生物信息学 蛋白别名: Homeobox protein SIX1; Sine oculis homeobox homolog 1 基因别名: BOS3; DFNA23; SIX1; TIP39 UniProt ID: (Human) Q15475 Entrez Gene ID: (Human) 6495 随时为您服务 获取常见问题的专家解答,或者直接联系我们的技术专家,咨询应用、设备、常规产品使用问题。 联系技术支持 ...
(2000)observedEVCexpression in developing bone (limb, vertebrae, and ribs), heart, kidney, and lung. Alternative splicing in the 3′ UTR, which could possibly lead to differences in mRNA stability and, thus, affect EVC protein expression, was observed. Also, overlap was detected between the ...