In addition to mammals and other vertebrates, eukaryotic protein kinase superfamily members have been identified and characterized from a wide range of other animal phyla, plants, fungi, and microorganisms. Hence, the protein kinase progenitor gene can be traced back to a time prior to the ...
AzadehHekmat,Ali AkbarSaboury, inProtein Kinase Inhibitors, 2022 Abstract Protein kinases, a large superfamily of ATP-dependent phosphotransferases, catalyze the reversible hydroxyl-phosphorylation of Tyr, Ser, or Thr residues of protein substrates, which signifies a major posttranslational signaling mech...
All SF(Pkinase, MAT1) members interact with MNAT1, which possesses a targeting factor for CDK-activating kinase, the MAT1 domain28. In another example, SF(Pkinase, TGF_beta_GS) is significantly enriched with the tyrosine kinase-like (TKL) group. Among members of this DMI subfamily, BMPR...
H. (2012). Diversity, classification and function of the plant protein kinase superfamily. Phil. Trans. R. Soc. B, 367, 2619-2639.Lehti-Shiu MD, Shiu SH. 2012. Diversity, classification and function of the plant protein kinase superfamily. Philosophical Transactions of the Royal Society B ...
we revealed that several candidate hub genes might be involved in resistance toFof-1 infection. These hub genes includedD6 PROTEIN KINASE LIKE 2(D6PKL2),LRR-RLK2 CLAVATA2,diacylglycerol kinase(DGK),ETHYLENE RESPONSE FACTOR72(ERF72) andglycosyltransferase(GT). Among these hub genes,CLAVATA2,DGK...
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification1 protein‐tyrosine kinaseprotein‐serine kinaseprotein phosphorylationAMP‐dependent protein kinaseThe eukaryotic protein kinases make up a large superfamily of ... SK Hanks,T Hunter - 《Faseb Journal》 被引量...
MAP kinase phosphatases (MKPs) are critical regulatory proteins in stress-dependent and hormone-related signalling pathways, and are highly conserved in vertebrates. However, other eukaryotes, like yeast and plants, have distinct MKPs apparently unrelated to the vertebrate analogues [50–53]. There ...
It has a protein kinase domain, a calmodulin-like domain with four conserved EF-hand motifs, an autoinhibitory junction domain, and an N-terminal variable region [22]. It also has potential N-terminal myristoylation and palmitoylation sites [22]. Previously, OsCPK9 expression in response to ...
Thecatalytic domainsof eukaryotic serine/threonine- and tyrosine-specificprotein kinasesare related in sequence, and belong to the eukaryoticprotein kinase(ePK) superfamily, which in turn is a subset of protein-kinase like (PKL) kinases that share a common fold andcatalytic mechanism. The major cont...
The 3′ tyrosine kinase domain of NTRK can be fused to the 5’ region of various partners (TPM3, TPR, LMNA, RBPMS, EML4, SPECC1L), resulting in a chimeric protein receptor with constitutive activation of the tyrosine kinase domain. NTRK fusions have been found in fibrosarcoma-like tumors...