Fischer S;Koeberle S C;Laufer S A.p38αmitogen-activated protein kinase inhibitors,a patent review(2005-2011).Expert Opin Ther Pat.2011.1843-1866Stefan Fischer,Solveigh C Koeberle,Stefan A Laufer. P38α mitogen-activated protein kinase inhibitors, a patent review (2005-2011)[J].Expert opinion...
The present invention further provides a method for treating solid tumors due to the tyrosine kinase inhibiting property.ELIEZER JESUS DE LACERDA BARREIROMARIA LETICIA DE CASTRO BARBOSALIDIA MOREIRA LIMASTEFAN ANDREAS LAUFERCARLOS MAURICIO RABELLO DE SANT'ANNA...
Target residence time plays a crucial role in the pharmacological activity of small molecule inhibitors. Little is known, however, about the underlying causes of inhibitor residence time at the molecular level, which complicates drug optimization process
Among the most widely pursued drug target class, the protein kinases3, p38α MAPK represents an intensively studied kinase, for which numerous inhibitors have been developed to date, but still no approved drug exists22. Conformational dynamics of this kinase on a longer timescale have been studied...
an optimized and versatile synthesis to pyridinylimidazole-type p38α mitogen activated protein kinase inhibitors Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed ... A El-Gokha,SA Laufer,P Koch...
The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.ALBRECHT, WOLFGANGLAUFER, STEFANSELIG, ROLANDKLVEKORN, PHILLIPPRFKE, BENT
Kovalente KinaseinhibitorenSelektivitätDrugs that function by covalent bond formation represent a considerable fraction of our repository of effective medicines but safety concerns and the complexity of developing covalent inhibitors has rendered covalent targeting a less attractive strategy for rational ...
The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.WOLFGANG ALBRECHTSTEFAN LAUFERROLAND SELIGPHILLIP KLVEKORNBENT PRFKE
The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.Albrecht WolfgangLaufer StefanSelig RolandKlvekorn PhillipPrfke Bent
in their Review on page4372, the successful development of these interesting inhibitors requires careful fine tuning of reactivity, precise positioning of the reactive moiety on a suitable ATP mimetic compound and careful characterization of these inhibitors in cells and in vivo.doi:10.1002/anie....