大多数激酶同时作用于丝氨酸和苏氨酸 (称为丝氨酸/苏氨酸激酶，protein serine/threonine kinases，PSKs)。PSKs 种类较多，包括蛋白激酶 A (protein kinase A, PKA)，蛋白激酶 C (protein kinase C, PKC)，钙/钙调素依赖性蛋白激酶 (Calcium/calmodulin dependent protein kinase, CaMK)，G 蛋白偶联受体激酶，cGMP...
It was found that activation of PKCϵ is required for A-MuLV-, but not GALV-, induced syncytium formation, whereas cell signaling through cyclic AMP to activate PKA inhibited the A-MuLV-induced fusion process. Further, activation of Raf protein kinase also is required for A-MuLV-induced ...
Protein kinase C-θ: signaling from the center of the T-cell synapse Christopher WArendt, ...Dan RLittman, inCurrent Opinion in Immunology, 2002 Protein kinase C-q has recently been shown to be critical for T-cell signaling. It links membrane-proximalTCRactivation to downstream production of...
Cell signaling molecules such as protein kinase C (PKC) have been shown to play critical roles in motor activity, development of the nervous system, and in learning and memory. PKC also has been shown to be associated with several neurological disorders including Alzheimer's disease, status ...
Brognard J, Hunter T. Protein kinase signaling networks in cancer. Curr Opin Genet Dev 2011;21:4-11.Brognard J , Hunter T . 2011 . Protein kinase signaling networks in cancer . Curr Opin Genet Dev 21 : 4 – 11 .Brognard, J. & Hunter, T. Protein kinase signaling networks in ...
GPI-linked proteins coassociate with intracellular tyrosine kinases in "lipid rafts" proposed to function as platforms for signal transduction and cytoskeletal reorganization. TCR activation requires both tyrosine kinase signals and cyto... M Moran,MC Miceli - 《Immunity》 被引量: 560发表: 1998年 Ca...
The PKA Activity research-use-only kit is a colorimetric activity assay designed for the quantification and detection of protein kinase A activity in cell lysates, tissue extracts and buffer samples. This complete, ready-to-use kit includes a PKA substrate-coated 96-well plate(s), PKA standard...
Natural mineralized scaffolds promote the dentinogenic potential of dental pulp stem cells via the mitogen-activated protein kinase signaling pathway. The selection of a suitable scaffold material is important for dentin tissue regeneration, as the characteristics of biomaterials can potentially influence.....
accelerated fibrosarcoma (RAF)-like protein kinases as central mediators of auxin-triggered phosphorylation across species. Genetic analysis connects this kinase to both auxin-triggered protein phosphorylation and rapid cellular response, thus identifying an ancient mechanism for fast auxin responses in the ...
GerardManning,TonyHunter, inHandbook of Cell Signaling (Second Edition), 2010 Publisher Summary Thecatalytic domainsof eukaryotic serine/threonine- and tyrosine-specificprotein kinasesare related in sequence, and belong to the eukaryoticprotein kinase(ePK) superfamily, which in turn is a subset of prot...