Discusses uveitis, an eye inflammation that sometimes attacks via an autoimmune reaction. Use of steroids to suppress the immune system; Possibility that retinal S antigen, retrieved from cow eyes, may be able to wean patients off of steroids without the uveitis flaring up.N.S....
LFA-1 (the heterodime integrin molecule CD11a/CD18) is expressed on mature T cells and binds to ICAM-1 (CD54) expressed on APCs and endothelial cells.193,258,289 The pathway greatly facilitates initial lymphocyte recruitment at sites of injury and inflammation.207 Adhesion pathways have been ...
G protein-coupled receptors (GPCRs) play important roles in inflammation. Inflammatory cells such as polymorphonuclear leukocytes (PMN), monocytes and macrophages express a large number of GPCRs for classic chemoattractants and chemokines. These receptor
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a d
Soy protein is a primary industrial food ingredient that has been studied for use as a microencapsulation carrier. Although consumer perception suffers due to its allergenicity, association with GM and environmental habitat destruction, and phytoestrogen fears, soy protein serves as an indicator of plant...
Phenolic compounds are ubiquitous plant secondary metabolites that possess various biological activities and are known to interact with proteins, altering their structure and properties. Therefore, interactions between these compounds and proteins has ga
inflammation, blood vessel wall permeability andapoptosisor programmed cell death (PCD). When inactive, protein C is a complex, dual chain combination of 419 amino acids linked by apeptideactivator. The previously mentioned biological precursors, such as thrombomodulin and endothelial protein C receptor...
Inflammation Low blood pressure Fever Intense activity High stress Kidney stones Taking aspirin every day Very low temperatures Conditions that damage yourkidneyscan also make you have too much protein in your urine. The two most common conditions are diabetes and high blood pressure. ...
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological processes. Although the classical PTMs, such as phosphorylatio
Women are born with all of their oocytes. The oocyte proteome must be maintained with minimal damage throughout the woman’s reproductive life, and hence for decades. Here we report that oocyte and ovarian proteostasis involves extreme protein longevity.