2. This sperm protein initiates a process called " egg activation " which sets off all the biological processes necessary for development of an embryo. 3. The active ingredient in the drug is inserted via the protein transferrin directly into the tumor. ...
Simultaneous loss of function in these two genes causes a multisystem disorder called AMeD syndrome (AMeDS), which is characterized by bone marrow failure (aplastic anaemia), intellectual disabilities (mental retardation) and developmental defects (dwarfism) due to the accumulation of endogenous ...
Akkermansia muciniphila, one of the most abundant members of the gut microbiota, is a promising next-generation probiotic agent owing to its role in regulating host health6,7. Accumulating evidence supports its beneficial effects in the maintenance of gut health and amelioration of inflammation, as...
Proteinglycosylationis the attachment of carbohydrate to theamino acid(aa) residue of the protein backbone. There are many types ofglycanmodifications present in the cell, specifically, theN-,O-,C-linked, andO-GlcNAc modifications (Figure 1)[1]. The abundant and commonly occurring types ofprotein...
The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but isoform-resolved proteomic analysis relies on a
Comparing blood plasma from 19- to 24-year-olds, 61- to 82-year-olds and umbilical cords, the researchers identified age-associated changes in a number of proteins. These changes, they suspected, might affect a brain structure called the hippocampus, which in both mice and humans is critical...
classified in a new category called DOT1L domain-containing lysine methyltransferases25. DOT1L contains a seven β-strand Rossmann-fold domain, which is commonly observed in class I methyltransferases, such as protein arginine methyltransferases (PRMTs), and is phylogenetically closer to PRMTs than ...
Protein biogenesis at the endoplasmic reticulum (ER) in eukaryotic cells is monitored by a protein quality control system named ER-associated protein degradation (ERAD). While there has been substantial progress in understanding how ERAD eliminates defective polypeptides generated from erroneous folding, ...
is a sequence-specific RNA-binding protein that binds to a 240-base region of a complex RNAsecondary structure, called the Rev response element (RRE) located in theviral envelopemRNA. This interaction permits unspliced mRNA to enter the cytoplasm from the nucleus and gives rise to theviral pr...
Protein synthesisRibosomes are key components of protein synthesis in cells. The common property of all proteins is that they consist of long chains ofα-amino (alpha amino) acids. The α-amino acids are so called because the α-carbonatomin themoleculecarries an amino group (―NH2); the ...