An exponential increase in the number of publications that address artificial intelligence (AI) usage in life sciences has been noticed in recent years, while new modeling techniques are constantly being reported. The potential of these methods is vast—
The interactions between the wild-type and mutant residues with the most negative ΔΔGAffinity and their nearby residues are shown in Figs. S10–S13. Moreover, the results of per-residue free energy decomposition analysis using the MM-GBSA method for the nsp16-nsp10 and nsp14-nsp10 ...
In addition, the authors compared per-protein features, which are computed independently for each protein in the pair, and per-pair features, which characterize the pairwise relationships between the proteins and are obtained using pair annotations, such as co-occurrences in the same subcellular ...
All the procedural steps were interceded by washing thrice (5 min each) in phosphate buffered saline (pH 7.4). Stained sections were examined under light microscope. Ten fields per tissue section covering highly cellular areas were counted under 40x magnification objective using image analysis ...
As we are dealing with interhelical interactions between different proteins embedded in the membrane, helix-pairing motifs are not directly comparable. However, we can look at the pairing motifs of TM proteins composed of a single TM α-helical domain, such as glycophorin A, presenting a G.{3...
In the first step in FINDER’s CPD, short read alignments to the genome are converted into number of read counts per nucleotide using bedtools [100]. A custom python script is used to transfer the per nucleotide coverage data from the genome to the transcriptome reported by PsiCLASS. Each ...
regulated by both heterotrimeric and Ras-superfamily G-proteins. AnArabidopsisprotein has been discovered containing both GPCR and RGS domains within the same protein. Most surprisingly, a receptor-independent Gα nucleotide cycle that regulates cell division has been delineated in bothCaenorhabditis ...
Judging from the monocyte chemotactic capacities of natural serum and the serum derived from plasma replaced with the recombinant RP S19, the plasma concentration of the RP S19-like molecule is assumed to be several hundred nanograms per milliliter. The experiments using factor XIII-deficient plasma...
In this work, we describe development of a SARS-CoV-2 antigen test using Simoa technology to quantify N-protein in serum/plasma, dried blood microsamples (DBS), and saliva. The assay was designed to target the SARS-CoV-2 nucleocapsid protein, due to the large copy number per viral ...
PER2 is one of the core genes of the circadian clock, it generates the circadian rhythms in the central nervous system and peripheral organs (Arjona and Sarkar, 2006a, Arjona and Sarkar, 2006b, Sujino et al., 2007). It plays a critical role in sleep, especially in familial advanced ...