For many proteins, the most prominent structural motif of the functional protein in its native conformation is known as the alpha helix, a right-handed spiral coil (Paulinget al. 1951). When a protein becomes toxic, an extensive conformational change occurs and it acquires a motif known as th...
Prenyl-binding protein (PrBP/δ) is a 17 kDa ubiquitous solubilization factor4,10,11. In its 3D structure, it is highly similar to other solubilization factors such as RhoGDI or UNC119 (uncoordination mutant 119 of C. elegans) despite a very low sequence identity of 10% and 24%, res...
Additionally, its presence in folded active regions of proteins is of great interest for therapeutic development.47 Sign in to download hi-res image Fig. 4. Miniprotein structures. (a) β-hairpin (PDB: 1E0Q), (b) WW-domain (PDB: 1E0M), (c) PPα (PDB: 6GWX), (d) Trp_Plexus57...
Dockerin-cohesin interactions SpyTag-SpyCatcher system 1. Introduction Nature has always witnessed the highly organized enzymatic complexes that drive various metabolic reactions with a high degree of specificity. Indeed, in its highly ordered form, enzymes work more efficiently with better substrate channe...
In this scenario, a protein hormone is secreted by a cell and released into the bloodstream. This hormone then reaches an anatomically distinct site where it binds to its receptor deployed at the surface of another cell (in another tissue). The present treatment is primarily concerned with ...
According to this view, a protein's function depends on its prior folding into a unique three-dimensional structure. In such cases, the amino acid sequence determines the protein's unique 3-D structure. Evidence is rapidly accumulating that many protein regions and even entire proteins lack ...
This accounts for its insolubility and resistance to all agents which do not break the peptide backbone.4. Resilin is a structure protein in which the primary chains show little or no tendency to form secondary structures; they are bound together in a uniform three-dimensional network (the ...
Simpleprotein:onlyconsistsofAAs(Native)Protein Conjugatedprotein:consistsofAAsandothers Apoprotein+prostheticgroup liguofu Theseproteinsarereferredasconjugatedproteinswhiletheaminoacidpartaloneiscalledapoprotein.liguofu §3ProteinStructure 三级结构和四级结构称为蛋白质的高级结构，都可以是一个蛋白质的终极结构；只有一...
(MS) has become a prominent technique in the field of structural biology due to its ability to provide structural information for proteins and protein complexes. MS can be particularly beneficial because it is faster, can work for heterogeneous samples, can be used routinely at all stages of a...
Ligand GA is introduced in this work and approaches the problem of finding small molecules inhibiting protein functions by using the protein site to find close to optimal or optimal small molecule binders. Genetic algorithms (GA) are an effective means f